Nanoparticles Improved Pheophorbide-a Mediated Photodynamic Therapy for Cancer

Overview

Journal Lasers Med Sci

Publisher Springer

Date 2025 Feb 7

PMID 39918741

Authors

Nosipho Fakudze

Heidi Abrahamse

Blassan George

Affiliations

Soon will be listed here.

Abstract

The increased cancer incidence and mortality rates have made researchers continue to explore different types of effective and less toxic cancer therapies. Photodynamic therapy (PDT) is an alternative cancer treatment modality with reduced side effects. It is comprised of three components, a photosensitizer, molecular oxygen and light. Researchers have been exploring third generation photosensitizers that overcome existing photosensitizer limitations such as hydrophobicity, accurate targeting and photosensitivity. Pheophorbide-a is a chlorophyll product currently being explored in a number of in vitro, in vivo and in silico studies as an ideal photosensitizer for breast, prostate, lung, oral squamous cell carcinoma, gastric, osteosarcoma and cervical cancers. These in vitro, in vivo and in silico studies have shown the probable cell death pathways in different cell lines and how advancement in using nanocarriers has improved cancer cell killing effect after pheophorbide-a mediated PDT. The pharmacokinetics have elaborated on the biodistribution and tissue disposition of pheophorbide-a in this review. In summary, we offer our viewpoint on PDT in the context of cancer management, and we believe that this article will shed new light on the role of pheophorbide-a in PDT for cancer.

References

Lemjabbar-Alaoui H, Hassan O, Yang Y, Buchanan P . Lung cancer: Biology and treatment options. Biochim Biophys Acta. 2015; 1856(2):189-210. PMC: 4663145. DOI: 10.1016/j.bbcan.2015.08.002. View

Joudeh N, Linke D . Nanoparticle classification, physicochemical properties, characterization, and applications: a comprehensive review for biologists. J Nanobiotechnology. 2022; 20(1):262. PMC: 9171489. DOI: 10.1186/s12951-022-01477-8. View

Senapathy G, George B, Abrahamse H . Enhancement of Phthalocyanine Mediated Photodynamic Therapy by Catechin on Lung Cancer Cells. Molecules. 2020; 25(21). PMC: 7659931. DOI: 10.3390/molecules25214874. View

Viera I, Chen K, Rios J, Benito I, Perez-Galvez A, Roca M . First-Pass Metabolism of Chlorophylls in Mice. Mol Nutr Food Res. 2018; 62(17):e1800562. DOI: 10.1002/mnfr.201800562. View

Kandagatla S, Uhl R, Graf T, Oberlies N, Raner G . Pheophorbide Derivatives Isolated from Açaí Berries () Activate an Antioxidant Response Element . Nat Prod Commun. 2020; 14(6). PMC: 7673296. DOI: 10.1177/1934578X19852443. View

Zhang Z, Wang K, Liu M, Hu P, Xu Y, Yin D . Phototherapeutic effect of transformable peptides containing pheophorbide a on colorectal cancer. Drug Deliv. 2022; 29(1):1608-1619. PMC: 9135428. DOI: 10.1080/10717544.2022.2075987. View

Fatima A, Yee H . In Silico Screening of Mutated K-Ras Inhibitors from Malaysian Typhonium flagelliforme for Non-Small Cell Lung Cancer. Adv Bioinformatics. 2014; 2014:431696. PMC: 4189522. DOI: 10.1155/2014/431696. View

Nagai Y, Aizawa S, Iriuchishima T, Goto B, Nagaoka M, Tokuhashi Y . Phototoxic effect of na-pheophorbide a toward osteosarcoma cells in vitro using a laser diode. Photomed Laser Surg. 2014; 32(9):481-9. DOI: 10.1089/pho.2014.3736. View

Tong Q, Xu J, Wu A, Zhang C, Yang A, Zhang S . Pheophorbide A-Mediated Photodynamic Therapy Potentiates Checkpoint Blockade Therapy of Tumor with Low PD-L1 Expression. Pharmaceutics. 2022; 14(11). PMC: 9697200. DOI: 10.3390/pharmaceutics14112513. View

10.

Moret F, Menilli L, Battan M, Tedesco D, Columbaro M, Guerrini A . Pheophorbide A and Paclitaxel Bioresponsive Nanoparticles as Double-Punch Platform for Cancer Therapy. Pharmaceutics. 2021; 13(8). PMC: 8399365. DOI: 10.3390/pharmaceutics13081130. View

11.

Verger A, Brandhonneur N, Molard Y, Cordier S, Kowouvi K, Amela-Cortes M . From molecules to nanovectors: Current state of the art and applications of photosensitizers in photodynamic therapy. Int J Pharm. 2021; 604:120763. DOI: 10.1016/j.ijpharm.2021.120763. View

12.

Bellnier D, Henderson B, Pandey R, Potter W, Dougherty T . Murine pharmacokinetics and antitumor efficacy of the photodynamic sensitizer 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a. J Photochem Photobiol B. 1993; 20(1):55-61. DOI: 10.1016/1011-1344(93)80131-r. View

13.

Ahn M, Yoon H, Moon S, Kim Y, Yoon J . Intratumoral Photodynamic Therapy With Newly Synthesized Pheophorbide a in Murine Oral Cancer. Oncol Res. 2016; 25(2):295-304. PMC: 7841246. DOI: 10.3727/096504016X14732527645922. View

14.

Cho H, Li L, Bae Y, Huh K, Kang H . Bioreducible branched polyethyleneimine derivatives physically loaded with hydrophobic pheophorbide A: preparation, characterization, and light-induced cytotoxicity. Macromol Biosci. 2014; 14(10):1483-94. DOI: 10.1002/mabi.201400145. View

15.

Zhang Y, Wang B, Zhao R, Zhang Q, Kong X . Multifunctional nanoparticles as photosensitizer delivery carriers for enhanced photodynamic cancer therapy. Mater Sci Eng C Mater Biol Appl. 2020; 115:111099. DOI: 10.1016/j.msec.2020.111099. View

16.

Ruiz-Gonzalez R, Milan P, Bresoli-Obach R, Stockert J, Villanueva A, Canete M . Photodynamic Synergistic Effect of Pheophorbide a and Doxorubicin in Combined Treatment against Tumoral Cells. Cancers (Basel). 2017; 9(2). PMC: 5332941. DOI: 10.3390/cancers9020018. View

17.

Yoo J, Park C, Yi G, Lee D, Koo H . Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems. Cancers (Basel). 2019; 11(5). PMC: 6562917. DOI: 10.3390/cancers11050640. View

18.

Alves S, Calori I, Tedesco A . Photosensitizer-based metal-organic frameworks for highly effective photodynamic therapy. Mater Sci Eng C Mater Biol Appl. 2021; 131:112514. DOI: 10.1016/j.msec.2021.112514. View

19.

Son J, Yang S, Yi G, Roh Y, Park H, Park J . Folate-modified PLGA nanoparticles for tumor-targeted delivery of pheophorbide a in vivo. Biochem Biophys Res Commun. 2018; 498(3):523-528. DOI: 10.1016/j.bbrc.2018.03.013. View

20.

Hodos R, Kidd B, Shameer K, Readhead B, Dudley J . In silico methods for drug repurposing and pharmacology. Wiley Interdiscip Rev Syst Biol Med. 2016; 8(3):186-210. PMC: 4845762. DOI: 10.1002/wsbm.1337. View