» Articles » PMID: 39912963

Piano Level Laser Therapy Versus Epidermal Growth Factor Injection for Painful Myogenic Temporomandibular Disorder (a Randomized Clinical Trial)

Overview
Date 2025 Feb 6
PMID 39912963
Authors
Affiliations
Soon will be listed here.
Abstract

Objective: The aim of this clinical trial was to evaluate the effectiveness of Piano level laser therapy using Nd-YAG laser and intramuscular EGF injection in pain alleviation, function, and quality of life improvement in patients suffering from myogenic TMD.

Materials And Methods: A randomized clinical trial was performed on 29 patients suffering from chronic painful myogenic TMD based on diagnostic criteria for temporomandibular disorders. Group I (n = 13patients) was treated using 1064 nm Nd-YAG Laser (4 sessions once/week). Group II (n = 14 patients) was treated by intramuscular injection of EGF. Pain using numerical rating score, pain free opening and unassisted maximum opening were measured at baseline, 7,14,21 days, 1 and 3 months. Quality of life using OHIP-14 was assessed at baseline, 1 and 3 months.

Results: Results showed that there was a significant pain reduction (P < 0.000) and increase in pain free opening (P < 0.0001) in both test groups. However, only group I showed a significant increase in maximum opening (P = 0.007). Quality of life significantly improved in both groups (P = 0.0001). There was no significant difference between the two treatments in pain scores, pain free opening, maximum opening nor quality of life.

Conclusion: Both treatment modalities offered effective and cost-effective non- to minimally invasive treatment options for myogenic TMD with no side effects.

Clinical Relevance: Myogenic TMD forms a public health issue and is a common musculoskeletal problem causing pain and disability. The proposal of effective, non-invasive, and affordable treatment options can help solve this issue.

References
1.
Wroblewski O, Vega-Soto E, Nguyen M, Cederna P, Larkin L . Impact of Human Epidermal Growth Factor on Tissue-Engineered Skeletal Muscle Structure and Function. Tissue Eng Part A. 2020; 27(17-18):1151-1159. PMC: 8558067. DOI: 10.1089/ten.TEA.2020.0255. View

2.
Yilmaz O, Sivrikaya E, Taskesen F, Pirpir C, Ciftci S . Comparison of the Efficacy of Botulinum Toxin, Local Anesthesia, and Platelet-Rich Plasma Injections in Patients With Myofascial Trigger Points in the Masseter Muscle. J Oral Maxillofac Surg. 2020; 79(1):88.e1-88.e9. DOI: 10.1016/j.joms.2020.09.013. View

3.
Al-Moraissi E, Alradom J, Aladashi O, Goddard G, Christidis N . Needling therapies in the management of myofascial pain of the masticatory muscles: A network meta-analysis of randomised clinical trials. J Oral Rehabil. 2020; 47(7):910-922. DOI: 10.1111/joor.12960. View

4.
Fernandes M, Ruta D, Ogden G, Pitts N, Ogston S . Assessing oral health-related quality of life in general dental practice in Scotland: validation of the OHIP-14. Community Dent Oral Epidemiol. 2006; 34(1):53-62. DOI: 10.1111/j.1600-0528.2006.00254.x. View

5.
Ekici O, Dundar U, Buyukbosna M . Effectiveness of high-intensity laser therapy in patients with myogenic temporomandibular joint disorder: A double-blind, placebo-controlled study. J Stomatol Oral Maxillofac Surg. 2021; 123(3):e90-e96. DOI: 10.1016/j.jormas.2021.06.009. View