Respiratory Support in Patients with Down Syndrome: a Systematic Review

Overview

Journal Eur Respir Rev

Date 2025 Feb 5

PMID 39909501

Authors

Paolo Ruggeri

Sara Manti

Alessandra Li Pomi

Federica Lo Bello

Giorgio Morana

Claudia Profazio

Mina Bushra

Antonio Esquinas

Affiliations

Soon will be listed here.

Abstract

Background: The population with Down syndrome (DS) makes up a significant portion of patients using short- and long-term noninvasive ventilation (NIV). However, limited data are available concerning the use and outcomes for patients with DS compared with other populations. We systematically reviewed articles providing indications, benefits, adherence and limits of long-term NIV use in the paediatric and adult population with DS.

Methods: A systematic review of the literature for articles published between January 2013 and November 2023 was conducted using a protocol registered at PROSPERO (CRD42023488712).

Results: In total, 18 studies focusing on the use of noninvasive respiratory support in patients with DS were included in this review. Obstructive sleep apnoea syndrome (OSAS), OSAS post-adenotonsillectomy, hypoventilation and nocturnal hypercapnia were the most common indications for NIV support in patients with DS. However, respiratory anatomical malformation and intellectual disabilities can affect adherence to NIV use. High-flow nasal cannula is an alternative to other noninvasive respiratory support.

Conclusion: Comprehensive and updated consensus compliant with international standards for clinical guidelines is required to significantly improve clinical practice quality, promote evidence-based recommendations and provide tailored interventions in patients with DS.

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