One Pot Synthesis of SeTe-ZnO Nanoparticles for Antibacterial and Wound Healing Applications

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Date 2025 Feb 5

PMID 39906629

Authors

Yushu Wang

Shahin Shah Khan

Irfan Ullah

Ahmed Rady

Badr Aldahmash

Yingjie Yu

Luo Liu

Xiulong Zhu

Affiliations

Soon will be listed here.

Abstract

Bacterial infections, particularly those involving biofilms, pose significant treatment challenges due to their resistance to traditional antibiotics. Herein, this research explores the integration of selenium-tellurium nanoparticles (SeTe NP) and zinc oxide (ZnO) NP to create hybrid NP with dual photodynamic and photothermal properties. The synthesized SeTe-ZnO NP demonstrated significant efficacy against both Gram-positive (), () and Gram-negative (), () bacteria, effectively disrupting biofilm formation and promoting wound healing. studies further confirmed the biocompatibility and superior wound healing capabilities of SeTe-ZnO NP, highlighting their potential as a versatile and effective treatment for bacterial infections and wound care.

References

Ye M, Zhao Y, Wang Y, Zhao M, Yodsanit N, Xie R . A Dual-Responsive Antibiotic-Loaded Nanoparticle Specifically Binds Pathogens and Overcomes Antimicrobial-Resistant Infections. Adv Mater. 2021; 33(9):e2006772. DOI: 10.1002/adma.202006772. View

Yu B, Wang Y, Bing T, Tang Y, Huang J, Xiao H . Platinum Prodrug Nanoparticles with COX-2 Inhibition Amplify Pyroptosis for Enhanced Chemotherapy and Immune Activation of Pancreatic Cancer. Adv Mater. 2023; 36(11):e2310456. DOI: 10.1002/adma.202310456. View

Yuan C, Zhang D, Tang Y, Guo Z, Lin K, Yu Y . Fibrous dressing containing bioactive glass with combined chemotherapy and wound healing promotion for post-surgical treatment of melanoma. Biomater Adv. 2023; 149:213387. DOI: 10.1016/j.bioadv.2023.213387. View

Li S, Yang Y, Wang S, Gao Y, Song Z, Chen L . Advances in metal graphitic nanocapsules for biomedicine. Exploration (Beijing). 2023; 2(6):20210223. PMC: 10191027. DOI: 10.1002/EXP.20210223. View

Laloux L, Kastrati D, Cambier S, Gutleb A, Schneider Y . The Food Matrix and the Gastrointestinal Fluids Alter the Features of Silver Nanoparticles. Small. 2020; 16(21):e1907687. DOI: 10.1002/smll.201907687. View

Li H, Yuan Y, Zhang L, Xu C, Xu H, Chen Z . Reprogramming Macrophage Polarization, Depleting ROS by Astaxanthin and Thioketal-Containing Polymers Delivering Rapamycin for Osteoarthritis Treatment. Adv Sci (Weinh). 2023; 11(9):e2305363. PMC: 10916582. DOI: 10.1002/advs.202305363. View

Fang G, Li W, Shen X, Perez-Aguilar J, Chong Y, Gao X . Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria. Nat Commun. 2018; 9(1):129. PMC: 5760645. DOI: 10.1038/s41467-017-02502-3. View

Bao X, Huo S, Wang Z, Yang S, Dou L, Liu Y . Multifunctional biomimetic hydrogel dressing provides anti-infection treatment and improves immunotherapy by reprogramming the infection-related wound microenvironment. J Nanobiotechnology. 2024; 22(1):80. PMC: 10902999. DOI: 10.1186/s12951-024-02337-3. View

Zhao Y, Zhang Z, Pan Z, Liu Y . Advanced bioactive nanomaterials for biomedical applications. Exploration (Beijing). 2023; 1(3):20210089. PMC: 10191050. DOI: 10.1002/EXP.20210089. View

10.

Li R, Chen Z, Dai Z, Yu Y . Nanotechnology assisted photo- and sonodynamic therapy for overcoming drug resistance. Cancer Biol Med. 2021; . PMC: 8185853. DOI: 10.20892/j.issn.2095-3941.2020.0328. View

11.

Khan S, Ullah I, Zada S, Ahmad A, Ahmad W, Xu H . Functionalization of Se-Te Nanorods with Au Nanoparticles for Enhanced Anti-Bacterial and Anti-Cancer Activities. Materials (Basel). 2022; 15(14). PMC: 9316951. DOI: 10.3390/ma15144813. View

12.

Ullah I, Khan S, Ahmad W, Liu L, Rady A, Aldahmash B . Silver incorporated SeTe nanoparticles with enhanced photothermal and photodynamic properties for synergistic effects on anti-bacterial activity and wound healing. RSC Adv. 2024; 14(27):18871-18878. PMC: 11167613. DOI: 10.1039/d4ra01343c. View

13.

Shah V, Medina-Cruz D, Vernet-Crua A, Truong L, Sotelo E, Mostafavi E . Pepper-Mediated Green Synthesis of Selenium and Tellurium Nanoparticles with Antibacterial and Anticancer Potential. J Funct Biomater. 2023; 14(1). PMC: 9867025. DOI: 10.3390/jfb14010024. View

14.

Makabenta J, Nabawy A, Li C, Schmidt-Malan S, Patel R, Rotello V . Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections. Nat Rev Microbiol. 2020; 19(1):23-36. PMC: 8559572. DOI: 10.1038/s41579-020-0420-1. View

15.

Xiong G, Huang D, Lu L, Luo X, Wang Y, Liu S . Near-Infrared-II Light Induced Mild Hyperthermia Activate Cisplatin-Artemisinin Nanoparticle for Enhanced Chemo/Chemodynamic Therapy and Immunotherapy. Small Methods. 2022; 6(9):e2200379. DOI: 10.1002/smtd.202200379. View

16.

Blackman L, Qu Y, Cass P, Locock K . Approaches for the inhibition and elimination of microbial biofilms using macromolecular agents. Chem Soc Rev. 2021; 50(3):1587-1616. DOI: 10.1039/d0cs00986e. View

17.

Yu Y, Tian R, Zhao Y, Qin X, Hu L, Zou J . Self-Assembled Corrole/Chitosan Photothermal Nanoparticles for Accelerating Infected Diabetic Wound Healing. Adv Healthc Mater. 2022; 12(16):e2201651. DOI: 10.1002/adhm.202201651. View

18.

Bu F, Kang X, Tang D, Liu F, Chen L, Zhang P . Enhancing near-infrared II photodynamic therapy with nitric oxide for eradicating multidrug-resistant biofilms in deep tissues. Bioact Mater. 2023; 33:341-354. PMC: 10724540. DOI: 10.1016/j.bioactmat.2023.11.006. View

19.

Sirelkhatim A, Mahmud S, Seeni A, Kaus N, Ann L, Mohd Bakhori S . Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism. Nanomicro Lett. 2018; 7(3):219-242. PMC: 6223899. DOI: 10.1007/s40820-015-0040-x. View

20.

Lochenie C, Duncan S, Zhou Y, Fingerhut L, Kiang A, Benson S . Photosensitizer-Amplified Antimicrobial Materials for Broad-Spectrum Ablation of Resistant Pathogens in Ocular Infections. Adv Mater. 2024; 36(31):e2404107. DOI: 10.1002/adma.202404107. View