TIMD4MHCⅡ Macrophages Preserve Heart Function Through Retnla

Overview

Journal JACC Basic Transl Sci

Date 2025 Feb 5

PMID 39906591

Authors

Danyang Zhang

Xuanhao Wang

Lianlian Zhu

Yuxing Chen

Chao Yang

Zhiwei Zhong

Xiangming Kong

Jinliang Nan

Chen Wang

Hengxun Hu

Jinghai Chen

Peng Shi

Xinyang Hu

Wei Zhu

Jianan Wang

Affiliations

Soon will be listed here.

Abstract

Genetic fate mapping confirmed the existence of the TIMD4MHCⅡ macrophage subset and showed that they were resident macrophages with minimal input from peripheral monocytes. Further, single-cell RNA sequencing revealed that could serve as the signature gene for TIMD4MHCⅡ macrophages. Administration of recombinant protein of the gene, RELMα, delayed the onset of heart failure, whereas either deletion of TIMD4MHCⅡ macrophages or macrophage-specific loss of facilitated heart failure progression.

Citing Articles

Precision Targeting of Cardiac Macrophage Subsets to Ameliorate Heart Failure.

Lantz C, Thorp E JACC Basic Transl Sci. 2025; 10(1):85-87.

PMID: 39958475 PMC: 11830252. DOI: 10.1016/j.jacbts.2024.10.013.

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