Maxim. Polysaccharide Attenuates Diabetes Through the Synergistic Impact of Lipid Metabolism and Modulating Gut Microbiota

Overview

Journal Curr Res Food Sci

Date 2025 Feb 5

PMID 39906503

Authors

Qiaoying Song

Kunpeng Zhang

Shuyan Li

Shaoting Weng

Affiliations

Soon will be listed here.

Abstract

Polysaccharide, a chain of sugars bound by glycosidic bonds, have a wide range of physiological activities, including hypoglycemic activity. In present study, we established T2DM mice models to explore the effects and mechanism of Maxim polysaccharide (TMSP1) on high-fat diet/streptozotocin (HF-STZ) induced diabetes mice. The results showed that high-fat diet significantly increased the oral glucose tolerance test (OGTT), viscera index, oxidative stress, impaired glucose tolerance, decreased body weight, immune response and short-chain fatty acid (SCFAs) content, and disrupted the balance of intestinal flora structure. However, after 6 weeks of TMSP1 intervention decreased lipid accumulation, ameliorated gut microbiota dysbiosis by increasing SCFAs-producing bacteria and mitigated intestinal inflammation and oxidative stress. Moreover, TMSP1 significantly restored the integrity of the intestinal epithelial barrier and mucus barrier. The results of fecal microbiota transplantation confirmed that TMSP1 exerted hypoglycemic effect through regulating intestinal flora to a certain extent. Collectively, the findings revealed TMSP1 intervention inhibits hyperglycemia by improving gut microbiota disorder, lipid metabolism, and inflammation. Hence, TMSP1 may be an effective measure to ameliorate HF-STZ induced diabetes.

References

Goyal S, Reddy N, Patil K, Nakhate K, Ojha S, Patil C . Challenges and issues with streptozotocin-induced diabetes - A clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics. Chem Biol Interact. 2015; 244:49-63. DOI: 10.1016/j.cbi.2015.11.032. View

Yi Y, Hua H, Sun X, Guan Y, Chen C . Rapid determination of polysaccharides and antioxidant activity of Poria cocos using near-infrared spectroscopy combined with chemometrics. Spectrochim Acta A Mol Biomol Spectrosc. 2020; 240:118623. DOI: 10.1016/j.saa.2020.118623. View

Chen G, Chen D, Zhou W, Peng Y, Chen C, Shen W . Improvement of Metabolic Syndrome in High-Fat Diet-Induced Mice by Yeast β-Glucan Is Linked to Inhibited Proliferation of and in Gut Microbiota. J Agric Food Chem. 2021; 69(27):7581-7592. DOI: 10.1021/acs.jafc.1c00866. View

Moheet A, Mangia S, Seaquist E . Impact of diabetes on cognitive function and brain structure. Ann N Y Acad Sci. 2015; 1353:60-71. PMC: 4837888. DOI: 10.1111/nyas.12807. View

Moon S, Rahman A, Kim J, Kee S . Hanultarin, a cytotoxic lignan as an inhibitor of actin cytoskeleton polymerization from the seeds of Trichosanthes kirilowii. Bioorg Med Chem. 2008; 16(15):7264-9. DOI: 10.1016/j.bmc.2008.06.032. View

Hu R, Zeng F, Wu L, Wan X, Chen Y, Zhang J . Fermented carrot juice attenuates type 2 diabetes by mediating gut microbiota in rats. Food Funct. 2019; 10(5):2935-2946. DOI: 10.1039/c9fo00475k. View

Cardullo N, Muccilli V, Pulvirenti L, Cornu A, Pouysegu L, Deffieux D . C-glucosidic ellagitannins and galloylated glucoses as potential functional food ingredients with anti-diabetic properties: a study of α-glucosidase and α-amylase inhibition. Food Chem. 2020; 313:126099. DOI: 10.1016/j.foodchem.2019.126099. View

Li Y, Xu S, Mihaylova M, Zheng B, Hou X, Jiang B . AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011; 13(4):376-388. PMC: 3086578. DOI: 10.1016/j.cmet.2011.03.009. View

Sanna S, van Zuydam N, Mahajan A, Kurilshikov A, Vich Vila A, Vosa U . Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. Nat Genet. 2019; 51(4):600-605. PMC: 6441384. DOI: 10.1038/s41588-019-0350-x. View

10.

Liu H, Amakye W, Ren J . Codonopsis pilosula polysaccharide in synergy with dacarbazine inhibits mouse melanoma by repolarizing M2-like tumor-associated macrophages into M1-like tumor-associated macrophages. Biomed Pharmacother. 2021; 142:112016. DOI: 10.1016/j.biopha.2021.112016. View

11.

Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L . A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice. Nat Med. 2016; 23(1):107-113. DOI: 10.1038/nm.4236. View

12.

Shen N, Jiang S, Lu J, Yu X, Lai S, Zhang J . The constitutive activation of Egr-1/C/EBPa mediates the development of type 2 diabetes mellitus by enhancing hepatic gluconeogenesis. Am J Pathol. 2014; 185(2):513-23. DOI: 10.1016/j.ajpath.2014.10.016. View

13.

Zhang W, Xiang Q, Zhao J, Mao G, Feng W, Chen Y . Purification, structural elucidation and physicochemical properties of a polysaccharide from Abelmoschus esculentus L (okra) flowers. Int J Biol Macromol. 2020; 155:740-750. DOI: 10.1016/j.ijbiomac.2020.03.235. View

14.

Zeng F, Yao Y, Wang L, Li W . Polysaccharides as antioxidants and prooxidants in managing the double-edged sword of reactive oxygen species. Biomed Pharmacother. 2023; 159:114221. DOI: 10.1016/j.biopha.2023.114221. View

15.

Cheng Y, Yu S, Xue F . Comparison of the Extraction Efficiency of Isoflavone Compounds from by Ionic Liquids with 11 Anions and 8 Imidazolium-Based Cations. ACS Omega. 2020; 5(15):8962-8971. PMC: 7178765. DOI: 10.1021/acsomega.0c00724. View

16.

Wu Y, Li A, Liu H, Zhang Z, Zhang C, Ma C . HNU082 alleviates dextran sulfate sodium-induced ulcerative colitis in mice through regulating gut microbiome. Food Funct. 2022; 13(19):10171-10185. DOI: 10.1039/d2fo02303b. View

17.

Kyrgiou M, Mitra A, Moscicki A . Does the vaginal microbiota play a role in the development of cervical cancer?. Transl Res. 2016; 179:168-182. PMC: 5164950. DOI: 10.1016/j.trsl.2016.07.004. View

18.

Shu S, Xie G, Guo X, Wang M . Purification and characterization of a novel ribosome-inactivating protein from seeds of Trichosanthes kirilowii Maxim. Protein Expr Purif. 2009; 67(2):120-5. DOI: 10.1016/j.pep.2009.03.004. View

19.

Zhan M, Liang X, Chen J, Yang X, Han Y, Zhao C . Dietary 5-demethylnobiletin prevents antibiotic-associated dysbiosis of gut microbiota and damage to the colonic barrier. Food Funct. 2023; 14(9):4414-4429. DOI: 10.1039/d3fo00516j. View

20.

Adams B, Cai J, Armstrong J, Herold M, Lu Y, Sun A . EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. Anticancer Drugs. 2005; 16(3):263-75. DOI: 10.1097/00001813-200503000-00005. View