Socio-demographic Disparities in Global Trends of Lip and Oral Cavity Neoplasms from 1990 to 2021

Overview

Journal Sci Rep

Date 2025 Feb 5

PMID 39905081

Authors

Amr Sayed Ghanem

Agnes Toth

Attila Csaba Nagy

Affiliations

Soon will be listed here.

Abstract

Oral cancer, the 13th most common globally, is primarily squamous cell carcinoma linked to tobacco, alcohol, and HPV. Despite advances in care, it remains a major health concern due to high mortality and its impact on quality of life. This study analyzed socio-demographic disparities in oral cancer burden using data from 1990 to 2021. We analyzed annual incidence, mortality, and DALYs across 204 countries, using age-standardized rates and the Socio-demographic Index (SDI) to assess development-related impacts. Statistical methods included Kruskal-Wallis tests, linear regression, joinpoint regression for trends, and Exponential Smoothing for forecasts (2022-2030), with analyses conducted in STATA and Python, and p < 0.05 as significant. Incidence was highest in high SDI countries, while mortality and DALYs were highest in low and middle SDI countries (p < 0.001). From 1990 to 2021, incidence increased (AAPC: 0.5-1.0%), while mortality (APC: - 0.5%) and DALYs (APC: - 0.6%) declined in low SDI regions. Significant disparities across SDI categories (p < 0.001) showed incidence rising with socio-demographic development (R = 0.102, p < 0.001), with high-middle SDI regions bearing the highest mortality and DALYs. These findings highlight the need for awareness, prevention, early detection, and accessible care, especially in lower SDI regions.

References

Shin Y, Choung H, Lee J, Rhyu I, Kim H . Association of Periodontitis with Oral Cancer: A Case-Control Study. J Dent Res. 2019; 98(5):526-533. DOI: 10.1177/0022034519827565. View

Fujiwara T, Eguchi T, Sogawa C, Ono K, Murakami J, Ibaragi S . Carcinogenic epithelial-mesenchymal transition initiated by oral cancer exosomes is inhibited by anti-EGFR antibody cetuximab. Oral Oncol. 2018; 86:251-257. DOI: 10.1016/j.oraloncology.2018.09.030. View

Harris J, Ritchie C, Hanna G, McCain J, Ji Y . The Inequitable Global Burden of Lip and Oral Cancers: Widening Disparities Across Countries. J Oral Maxillofac Surg. 2021; 79(6):1364-1372. DOI: 10.1016/j.joms.2020.12.035. View

Van Dyne E, Henley S, Saraiya M, Thomas C, Markowitz L, Benard V . Trends in Human Papillomavirus-Associated Cancers - United States, 1999-2015. MMWR Morb Mortal Wkly Rep. 2018; 67(33):918-924. PMC: 6107321. DOI: 10.15585/mmwr.mm6733a2. View

Cunha A, Compton K, Xu R, Mishra R, Drangsholt M, Antunes J . The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories: A Systematic Analysis for the Global Burden of Disease Study 2019. JAMA Oncol. 2023; 9(10):1401-1416. PMC: 10485745. DOI: 10.1001/jamaoncol.2023.2960. View

Abbas S, Tariq M, Raheem A, Saeed J, Hashmi S, Karim M . Assessment of Factors Affecting Quality of Life in Oral Squamous Cell Carcinoma Patients Using University of Washington Quality of Life Questionnaire. Cureus. 2019; 11(1):e3904. PMC: 6424547. DOI: 10.7759/cureus.3904. View

. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024; 403(10440):2162-2203. PMC: 11120204. DOI: 10.1016/S0140-6736(24)00933-4. View

Peng J, Hu Q, Chen X, Wang C, Zhang J, Ren X . Diet-induced obesity accelerates oral carcinogenesis by recruitment and functional enhancement of myeloid-derived suppressor cells. Cell Death Dis. 2021; 12(10):946. PMC: 8516872. DOI: 10.1038/s41419-021-04217-2. View

Collatuzzo G, Teglia F, Boffetta P . Role of Occupation in Shaping Cancer Disparities. Cancers (Basel). 2022; 14(17). PMC: 9454748. DOI: 10.3390/cancers14174259. View

10.

Osarogiagbon R, Sineshaw H, Unger J, Acuna-Villaorduna A, Goel S . Immune-Based Cancer Treatment: Addressing Disparities in Access and Outcomes. Am Soc Clin Oncol Educ Book. 2021; 41:1-13. DOI: 10.1200/EDBK_323523. View

11.

Sofi-Mahmudi A, Masinaei M, Shamsoddin E, Tovani-Palone M, Heydari M, Shoaee S . Global, regional, and national burden and quality of care index (QCI) of lip and oral cavity cancer: a systematic analysis of the Global Burden of Disease Study 1990-2017. BMC Oral Health. 2021; 21(1):558. PMC: 8561915. DOI: 10.1186/s12903-021-01918-0. View

12.

Owens D, Paleri V, Jones A . Head and neck cancer explained: an overview of management pathways. Br Dent J. 2022; 233(9):721-725. PMC: 9650163. DOI: 10.1038/s41415-022-5199-1. View

13.

Perez M, Raimondi A, Itoiz M . An experimental model to demonstrate the carcinogenic action of oral chronic traumatic ulcer. J Oral Pathol Med. 2004; 34(1):17-22. DOI: 10.1111/j.1600-0714.2004.00249.x. View

14.

Heller M, Nyirjesy S, Balsiger R, Talbot N, Vankoevering K, Haring C . Modifiable risk factors for oral cavity cancer in non-smokers: A systematic review and meta-analysis. Oral Oncol. 2023; 137:106300. DOI: 10.1016/j.oraloncology.2022.106300. View

15.

Schutte H, Heutink F, Wellenstein D, van den Broek G, van den Hoogen F, Marres H . Impact of Time to Diagnosis and Treatment in Head and Neck Cancer: A Systematic Review. Otolaryngol Head Neck Surg. 2020; 162(4):446-457. DOI: 10.1177/0194599820906387. View

16.

Salahshourifar I, Vincent-Chong V, Kallarakkal T, Zain R . Genomic DNA copy number alterations from precursor oral lesions to oral squamous cell carcinoma. Oral Oncol. 2014; 50(5):404-12. DOI: 10.1016/j.oraloncology.2014.02.005. View

17.

Khavinson V, Popovich I, Mikhailova O . Towards realization of longer life. Acta Biomed. 2020; 91(3):e2020054. PMC: 7716987. DOI: 10.23750/abm.v91i3.10079. View

18.

Chamoli A, Gosavi A, Shirwadkar U, Wangdale K, Behera S, Kurrey N . Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics. Oral Oncol. 2021; 121:105451. DOI: 10.1016/j.oraloncology.2021.105451. View

19.

Huang J, Chan S, Ko S, Lok V, Zhang L, Lin X . Disease burden, risk factors, and trends of lip, oral cavity, pharyngeal cancers: A global analysis. Cancer Med. 2023; 12(17):18153-18164. PMC: 10524054. DOI: 10.1002/cam4.6391. View

20.

Puska P, Daube M . Impact assessment of the WHO Framework Convention on Tobacco Control: introduction, general findings and discussion. Tob Control. 2018; 28(Suppl 2):s81-s83. PMC: 6589462. DOI: 10.1136/tobaccocontrol-2018-054429. View