ESPGHAN and NASPGHAN 2024 Protocol for Paediatric Functional Constipation Treatment Guidelines (standard Operating Procedure)

Overview

Journal BMJ Paediatr Open

Publisher BMJ Publishing Group

Date 2025 Feb 4

PMID 39904543

Authors

Morris Gordon

Anna de Geus

Marcin Banasiuk

Marc A Benninga

Osvaldo Borrelli

Mary Boruta

Anil Darbari

Dawn Dore-Stites

Michelle Gould

Juliette Hawa

Kirsten Brooke Jones

Julie Khlevner

Alexandra Kilgore

Hayat Mousa

Samuel Nurko

Vassiliki Sinopoulou

Merit Tabbers

Nikhil Thapar

Affiliations

Soon will be listed here.

Abstract

Introduction: Functional constipation is common in childhood, with chronicity leading to a significant impact on patients and their families. There is a significant range of therapies available to healthcare professionals for this condition, with many novel or recently studied. There is a need for an update to the joint European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)/North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) guidelines last released in 2014. We present the prospectively agreed operating procedure and technical review protocol in this manuscript.

Methods: 'Grading of Recommendations Assessment, Development and Evaluation' (GRADE) will be used for all phases of this guideline development. The Guideline Development Group is formed by paediatric gastroenterologists from both the ESPGHAN as well as the NASPGHAN. A prospective exercise will agree on key outcomes, thresholds of magnitude that are significant at small, moderate and large levels. Systematic evidence searches, selection, extraction, appraisal and analysis will be performed following Cochrane guidance and GRADE guidance for objectively agreeing the certainty of findings. Additional use of network meta-analysis will identify areas of broad triangulation in the evidence. Summary of findings tables will be produced and inform evidence to decision frameworks. These will guide GRADE recommendations with voting to reach a consensus.

Citing Articles

Do Most Children with Functional Constipation Meet the Commonly Used Clinical Trial Endpoints?.

Arrizabalo S, Velasco-Benitez C, Velasco-Suarez D, Giner R, Saps M Children (Basel). 2025; 12(2).

PMID: 40003336 PMC: 11854065. DOI: 10.3390/children12020234.

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