Unlocking the Potential of Hydrogen Deuterium Exchange Via an Iterative Continuous-flow Deuteration Process

Overview

Journal Nat Commun

Date 2025 Feb 3

PMID 39900624

Authors

Kevin Tatoueix

Marco Lepron

Cedric Barboux

Marie-Christine Scherrmann

Gregory Pieters

Sophie Feuillastre

Affiliations

Soon will be listed here.

Abstract

Labelled compounds bearing hydrogen isotopes are keystones in diverse areas constituting a multi-billion dollar global market including drugs, diagnostics, biology, toxicology and smart materials. While hydrogen deuterium exchange (HDE) methods hold promise as relevant tools for the late-stage and one-step preparation of deuterium-labelled compounds, they often fall short in achieving sufficient isotopic purity combined either with a site-selectivity or with a full deuteration process, highlighting the need for further development and optimisation. This report pinpoints an approach to unlock the potential of HDE using the concept of iterative runs in continuous-flow technology (recirculation process). This closed-loop process grants access now to deuterated compounds with high isotopic purities, labelled at a precise site or perdeuterated on demand, in a fast, productive, and environmentally friendly way.

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