Spinal Metastasis Pain Surveillance: A Comprehensive Imaging-Based Tool Design for Evaluating Metastatic Burden and Guiding Therapeutic Strategies

Overview

Journal Int J Med Sci

Date 2025 Feb 3

PMID 39898244

Authors

Shuxin Kong

Aishi Deng

Zeyin Guo

Lijia Ma

Xi Su

Junwei Cui

Yongkang Ou

Jinghua Liu

Tao Qin

Zeng Fang

Affiliations

Soon will be listed here.

Abstract

The current research aims to elucidate the interplay between the anatomical distribution of spinal metastases, MRI features, and the intensity of bone pain in patients with breast cancer. A retrospective analysis was used on a cohort of 45 breast cancer patients with verified spinal metastases, examining the relationship between metastatic locations, MRI-derived metrics, and bone pain scores. The Visual Analogue Scale (VAS) was conducted to measure the severity of bone pain. The results revealed a significant association between lumbar spine metastases and elevated pain scores, outpacing those observed in thoracic and cervical regions. Furthermore, a strong correlation was found between the multiplicity of metastatic sites and the ratio of high-intensity areas on MRI, both of which were predictive of increased pain severity. The study's outcomes indicate that distinct MRI profiles, including the number and location of spinal metastases, can serve as prognostic indicators of bone pain intensity in breast cancer patients. Our data highlighted the need for personalized pain management strategies and targeted interventions tailored to specific imaging characteristics. Ultimately, this research underscores the dual role of MRI in both detecting spinal metastases and informing symptom management, with the potential to augment the overall well-being of breast cancer patients with spinal involvement.

References

Chen L, Tian Q, Shi Z, Qiu Y, Lu Q, Liu C . Melatonin Alleviates Cardiac Function in Sepsis-Caused Myocarditis Maintenance of Mitochondrial Function. Front Nutr. 2021; 8:754235. PMC: 8542660. DOI: 10.3389/fnut.2021.754235. View

Li J, Liang X, Wang X, Yang P, Jian X, Fu L . A missense variant causes brachydactyly type A1 and multiple-synostoses syndrome 2. JOR Spine. 2024; 7(1):e1302. PMC: 10782059. DOI: 10.1002/jsp2.1302. View

Yang Y, Wu Q, Pan W, Wen L, Luo Z, Wu H . Characteristics of the Ocular Surface in Myopic Child Candidates of Orthokeratology Lens Wear. Ophthalmol Ther. 2023; 12(6):3067-3079. PMC: 10640462. DOI: 10.1007/s40123-023-00793-y. View

Lin L, Wu Q, Lu F, Lei J, Zhou Y, Liu Y . Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers. Front Oncol. 2023; 13:1184079. PMC: 10559910. DOI: 10.3389/fonc.2023.1184079. View

Li H, Wang X, Liu Y, Pan D, Wang Y, Yang N . Hepatoprotection and hepatotoxicity of Heshouwu, a Chinese medicinal herb: Context of the paradoxical effect. Food Chem Toxicol. 2016; 108(Pt B):407-418. DOI: 10.1016/j.fct.2016.07.035. View

Feng M, Liu C, Chen L, Feng W, Liu M, Hai H . MiR-21 attenuates apoptosis-triggered by amyloid-β via modulating PDCD4/ PI3K/AKT/GSK-3β pathway in SH-SY5Y cells. Biomed Pharmacother. 2018; 101:1003-1007. DOI: 10.1016/j.biopha.2018.02.043. View

Zhang Y, Zhai M, Chen Z, Han X, Yu F, Li Z . Dual-modified liposome codelivery of doxorubicin and vincristine improve targeting and therapeutic efficacy of glioma. Drug Deliv. 2017; 24(1):1045-1055. PMC: 8240983. DOI: 10.1080/10717544.2017.1344334. View

Ding L, Lu S, Zhou Y, Lyu D, Ouyang C, Ma Z . The 3' Untranslated Region Protects the Heart from Angiotensin II-Induced Cardiac Dysfunction via AGGF1 Expression. Mol Ther. 2020; 28(4):1119-1132. PMC: 7132794. DOI: 10.1016/j.ymthe.2020.02.002. View

Zhao F, Ding G, Huang W, Li M, Fu Z, Yang G . FDG-PET Predicts Pain Response and Local Control in Palliative Radiotherapy With or Without Systemic Treatment in Patients With Bone Metastasis From Non-small-cell Lung Cancer. Clin Lung Cancer. 2015; 16(6):e111-9. DOI: 10.1016/j.cllc.2015.01.005. View

10.

Cao Y, Lan W, Wen L, Li X, Pan L, Wang X . An effectiveness study of a wearable device (Clouclip) intervention in unhealthy visual behaviors among school-age children: A pilot study. Medicine (Baltimore). 2020; 99(2):e17992. PMC: 6959882. DOI: 10.1097/MD.0000000000017992. View

11.

Ma P, Luo Q, Chen J, Gan Y, Du J, Ding S . Intraperitoneal injection of magnetic Fe₃O₄-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice. Int J Nanomedicine. 2012; 7:4809-18. PMC: 3439859. DOI: 10.2147/IJN.S34349. View

12.

Miyazaki S, Kakutani K, Sakai Y, Ejima Y, Maeno K, Takada T . Quality of life and cost-utility of surgical treatment for patients with spinal metastases: prospective cohort study. Int Orthop. 2017; 41(6):1265-1271. DOI: 10.1007/s00264-017-3463-9. View

13.

Xiong T, Xia L, Song Q . Circular RNA SPI1 expression before and after induction therapy and its correlation with clinical features, treatment response, and survival of acute myeloid leukemia patients. J Clin Lab Anal. 2023; 37(3):e24835. PMC: 9978078. DOI: 10.1002/jcla.24835. View

14.

Liang T, Zhang Y, Wu S, Chen Q, Wang L . The Role of NLRP3 Inflammasome in Alzheimer's Disease and Potential Therapeutic Targets. Front Pharmacol. 2022; 13:845185. PMC: 8889079. DOI: 10.3389/fphar.2022.845185. View

15.

Ma P, Wu Y, Zeng Q, Gan Y, Chen J, Ye X . Oxidative damage induced by chlorpyrifos in the hepatic and renal tissue of Kunming mice and the antioxidant role of vitamin E. Food Chem Toxicol. 2013; 58:177-83. DOI: 10.1016/j.fct.2013.04.032. View

16.

Huang Z, Yu P, Tang J . Characterization of Triple-Negative Breast Cancer MDA-MB-231 Cell Spheroid Model. Onco Targets Ther. 2020; 13:5395-5405. PMC: 7295545. DOI: 10.2147/OTT.S249756. View

17.

Li H, Shi W, Shen T, Hui S, Hou M, Wei Z . Network pharmacology-based strategy for predicting therapy targets of Ecliptae Herba on breast cancer. Medicine (Baltimore). 2023; 102(41):e35384. PMC: 10578738. DOI: 10.1097/MD.0000000000035384. View

18.

Sutcliffe P, Connock M, Shyangdan D, Court R, Kandala N, Clarke A . A systematic review of evidence on malignant spinal metastases: natural history and technologies for identifying patients at high risk of vertebral fracture and spinal cord compression. Health Technol Assess. 2013; 17(42):1-274. PMC: 4781430. DOI: 10.3310/hta17420. View

19.

Dong H, Li H, Wang L, Yuan Y, Zhang D, Zhou L . Clinical analysis of 175 cases of vaginal intraepithelial neoplasia. Eur J Obstet Gynecol Reprod Biol. 2023; 287:232-236. DOI: 10.1016/j.ejogrb.2023.06.020. View

20.

Zhang Y, Zhang Y, Liu S, Li B, Song Z, Han Q . Acupuncture for cancer pain: a scoping review of systematic reviews and meta-analyses. Front Oncol. 2023; 13:1169458. PMC: 10226720. DOI: 10.3389/fonc.2023.1169458. View