Frequency of Orthostatic Hypotension in the Pooled Resource Open-Access ALS Clinical Trials Database

Overview

Journal Front Neurol

Date 2025 Feb 3

PMID 39897942

Authors

C Quarracino

F Capani

M Otero-Losada

G E Rodriguez

S Perez-Lloret

Affiliations

Soon will be listed here.

Abstract

Purpose: To explore the frequency of orthostatic hypotension (OH) in a large sample of amyotrophic lateral sclerosis patients (ALS).

Methods: From the PRO-ACT database, data of 1,240 ALS patients were analyzed, focusing on blood pressure and heart rate before and after standing. OH was defined as a drop in systolic/diastolic blood pressure > 20/10 mm Hg within 3 min of standing. Neurogenic OH was diagnosed when the heart rate increase was below 15 bpm in patients not taking medications that could affect this response.

Results: At baseline, 138 (11.1%) patients showed OH, 76.1% of whom had neurogenic OH. At follow-up, 163 patients (13.1%) had OH, 71.2% with neurogenic OH. Only 22.5% of the patients with OH at baseline had OH at follow-up.

Conclusion: In a large sample of ALS patients, OH occurred in 11-13%, pointing to a subgroup that might require special care to avoid related complications.

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