Structural and Functional Changes of Post-Stroke Depression: A Multimodal Magnetic Resonance Imaging Study

Overview

Journal Neuroimage Clin

Publisher Elsevier

Date 2025 Feb 2

PMID 39893709

Authors

Qiuhong Lu

Shunzu Lu

Xue Wang

Yanlan Huang

Jie Liu

Zhijian Liang

Affiliations

Soon will be listed here.

Abstract

This study investigated changes in gray matter volume (GMV), white matter microstructure, and spontaneous brain activity in post-stroke depression (PSD) using multiple MRI techniques, including neurite orientation dispersion and density imaging (NODDI). Changes in GMV, neurite density index (NDI), orientation dispersion index (ODI), fraction of isotropic water (ISO), diffusion tensor imaging (DTI) parameters, and the amplitude of frequency fluctuations (ALFF) were assessed between PSD (n = 20), post-stroke without depression (n = 20), and normal control (n = 20) groups. Receiver operating characteristic (ROC) curve analysis was performed to test the classification performance of the variant parameters of each MRI modality, each single MRI modality and multiple MRI modality. Compared to patients with post-stroke without depression (non-PSD), those with PSD showed increased ODI and ISO in the widespread white matter, as well as increased ALFF in the left pallidum. No significant differences in the GMV or DTI parameters were observed between the two groups. Furthermore, the ODI of the right superior longitudinal fasciculus and NODDI showed the best classification performance for PSD at their respective comparison level (the areas under the ROC curves (AUC) = 0.917(0.000), 0.933(0.000)). The model of NODDI-derived parameters combined with non-diffusion MRI modality parameters (i.e., GMV and ALFF) showed better diagnostic performance than that of DTI-derived parameters. These findings suggest that PSD is associated with structural and functional abnormalities that may contribute to depressive symptoms. Additionally, NODDI showed its advantages in the description of structural alterations in emotion-related white matter pathways and classification performance in PSD.

References

Fu X, Shrestha S, Sun M, Wu Q, Luo Y, Zhang X . Microstructural White Matter Alterations in Mild Cognitive Impairment and Alzheimer's Disease : Study Based on Neurite Orientation Dispersion and Density Imaging (NODDI). Clin Neuroradiol. 2019; 30(3):569-579. DOI: 10.1007/s00062-019-00805-0. View

Guo J, Wang J, Sun W, Liu X . The advances of post-stroke depression: 2021 update. J Neurol. 2021; 269(3):1236-1249. DOI: 10.1007/s00415-021-10597-4. View

Philipsson J, Sjoberg R, Yelnik J, Blomstedt P . Acute severe depression induced by stimulation of the right globus pallidus internus. Neurocase. 2017; 23(1):84-87. DOI: 10.1080/13554794.2017.1284243. View

Nixon N, Guo B, Garland A, Kaylor-Hughes C, Nixon E, Morriss R . The bi-factor structure of the 17-item Hamilton Depression Rating Scale in persistent major depression; dimensional measurement of outcome. PLoS One. 2020; 15(10):e0241370. PMC: 7588071. DOI: 10.1371/journal.pone.0241370. View

Zhou L, Wang L, Wang M, Dai G, Xiao Y, Feng Z . Alterations in white matter microarchitecture in adolescents and young adults with major depressive disorder: A voxel-based meta-analysis of diffusion tensor imaging. Psychiatry Res Neuroimaging. 2022; 323:111482. DOI: 10.1016/j.pscychresns.2022.111482. View

Shen X, Fan Z, Wang L, Cui S, Niu J . Altered white matter microstructure in patients with post-stroke depression detected by diffusion kurtosis imaging. Neurol Sci. 2019; 40(10):2097-2103. DOI: 10.1007/s10072-019-03947-8. View

Colgan N, Siow B, OCallaghan J, Harrison I, Wells J, Holmes H . Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease. Neuroimage. 2015; 125:739-744. PMC: 4692518. DOI: 10.1016/j.neuroimage.2015.10.043. View

Goodin P, Lamp G, Vidyasagar R, Connelly A, Rose S, Campbell B . Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores. Neural Plast. 2019; 2019:2357107. PMC: 6701282. DOI: 10.1155/2019/2357107. View

Tournier J, Smith R, Raffelt D, Tabbara R, Dhollander T, Pietsch M . MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation. Neuroimage. 2019; 202:116137. DOI: 10.1016/j.neuroimage.2019.116137. View

10.

Oestreich L, Wright P, OSullivan M . Microstructural changes in the reward system are associated with post-stroke depression. Neuroimage Clin. 2020; 28:102360. PMC: 7426585. DOI: 10.1016/j.nicl.2020.102360. View

11.

Guo H, Guo J, Gao Z, Luo F, Zhang E . The role of amygdala-ventral pallidum pathway in depression-like behaviors in male mice. J Neurosci Res. 2023; 102(1):e25258. DOI: 10.1002/jnr.25258. View

12.

Rakic M, Cabezas M, Kushibar K, Oliver A, Llado X . Improving the detection of autism spectrum disorder by combining structural and functional MRI information. Neuroimage Clin. 2020; 25:102181. PMC: 6994708. DOI: 10.1016/j.nicl.2020.102181. View

13.

Churchill N, Caverzasi E, Graham S, Hutchison M, Schweizer T . White matter during concussion recovery: Comparing diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI). Hum Brain Mapp. 2018; 40(6):1908-1918. PMC: 6865569. DOI: 10.1002/hbm.24500. View

14.

Liu B, Cao Y, Wang J, Dong J . Excitatory transmission from ventral pallidum to lateral habenula mediates depression. World J Biol Psychiatry. 2020; 21(8):627-633. DOI: 10.1080/15622975.2020.1725117. View

15.

Ye C, Wu J, Chen X, Zhang C, Li H, Mao S . Structural changes of cingulate cortex in post stroke depression. Annu Int Conf IEEE Eng Med Biol Soc. 2017; 2016:1099-1102. DOI: 10.1109/EMBC.2016.7590895. View

16.

Egorova N, Veldsman M, Cumming T, Brodtmann A . Fractional amplitude of low-frequency fluctuations (fALFF) in post-stroke depression. Neuroimage Clin. 2017; 16:116-124. PMC: 5537409. DOI: 10.1016/j.nicl.2017.07.014. View

17.

Dalby R, Frandsen J, Chakravarty M, Ahdidan J, Sorensen L, Rosenberg R . Depression severity is correlated to the integrity of white matter fiber tracts in late-onset major depression. Psychiatry Res. 2010; 184(1):38-48. DOI: 10.1016/j.pscychresns.2010.06.008. View

18.

Oehr L, Yang J, Chen J, Maller J, Seal M, Anderson J . Investigating White Matter Tract Microstructural Changes at Six-Twelve Weeks following Mild Traumatic Brain Injury: A Combined Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging Study. J Neurotrauma. 2020; 38(16):2255-2263. DOI: 10.1089/neu.2020.7310. View

19.

Lai C, Wu Y . Alterations in white matter micro-integrity of the superior longitudinal fasciculus and anterior thalamic radiation of young adult patients with depression. Psychol Med. 2014; 44(13):2825-32. DOI: 10.1017/S0033291714000440. View

20.

Ji Y, Shen Z, Zhang X, Zhang K, Jia T, Xu X . Plasticity in ventral pallidal cholinergic neuron-derived circuits contributes to comorbid chronic pain-like and depression-like behaviour in male mice. Nat Commun. 2023; 14(1):2182. PMC: 10110548. DOI: 10.1038/s41467-023-37968-x. View