Surgical Outcomes of Adenoid Cystic Carcinoma Treated with Mohs Micrographic Surgery and Excision: a Systematic Review

Overview

Journal Arch Dermatol Res

Date 2025 Feb 1

PMID 39893263

Authors

Neha Arora

Ashley Wittmer

Mojahed Mohammad K Shalabi

Frank Jing

Umer Nadir

Benjamin F Kelley

Stanislav N Tolkachjov

Affiliations

Soon will be listed here.

Abstract

Adenoid cystic carcinoma (ACC) is a rare cancer that most commonly occurs in the salivary glands, making up approximately 2-4% of all head and neck malignancies. Treatment for ACC varies, with combinations of surgical excision, adjuvant radiotherapy, and chemotherapy reported in the literature. In this study, we aim to assess ACC recurrence rates with Mohs Micrographic Surgery (MMS) treatment compared to traditional wide local excision (WLE). In June of 2024, a comprehensive review of the literature was performed using the following keywords: "Adenoid Cystic Carcinoma" and/or "Mohs Micrographic Surgery" and/or "MMS" and/or "excision." Between the two databases, 25 articles were identified which included a total of 30 patients. Among all the articles, 30 procedures were documented - 8 MMS and 22 WLE. Patients with ACC treated with WLE had a higher rate of recurrence (40.9%) compared to those treated with MMS (12.5%). Limitations include a small number of tumors treated and reporting bias. MMS for the treatment of ACC demonstrated a decreased recurrence rate compared to WLE. Further studies with larger sample sizes are needed to confirm the benefit of MMS over WLE.

References

Chae Y, Chung S, Davis A, Carneiro B, Chandra S, Kaplan J . Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling. Oncotarget. 2015; 6(35):37117-34. PMC: 4741919. DOI: 10.18632/oncotarget.5076. View

Chummun S, McLean N, Kelly C, Dawes P, Meikle D, Fellows S . Adenoid cystic carcinoma of the head and neck. Br J Plast Surg. 2001; 54(6):476-80. DOI: 10.1054/bjps.2001.3636. View

Cacchi C, Persechino S, Fidanza L, Bartolazzi A . A primary cutaneous adenoid-cystic carcinoma in a young woman. Differential diagnosis and clinical implications. Rare Tumors. 2011; 3(1):e3. PMC: 3070451. DOI: 10.4081/rt.2011.e3. View

Krasevic M, Haller H, Iternicka Z, Valstelic I, Matejcic N . Adenoid cystic carcinoma of Bartholin's gland: a case report. Eur J Gynaecol Oncol. 2001; 22(3):213-4. View

Ronquillo C, Vegunta S, Ellis N, Mamalis N, Patel B . Adenoid Cystic Carcinoma of the Eyelid Can Locally Recur and Mimic Basal Cell Carcinoma: Case Report and Review of the Literature. Ophthalmic Plast Reconstr Surg. 2020; 36(5):e112-e116. DOI: 10.1097/IOP.0000000000001619. View

Duarte A, Costa D, Cacador N, Boavida A, Afonso A, Vilares M . Adenoid cystic carcinoma of the palpebral lobe of the lacrimal gland - case report and literature review. Orbit. 2021; 41(5):605-610. DOI: 10.1080/01676830.2021.1901293. View

Kim J, Roh M, Chung K . Immediate Umbilical Reconstruction after a Mohs Micrographic Surgery for Primary Cutaneous Adenoid Cystic Carcinoma Arising in the Umbilicus. Ann Dermatol. 2021; 31(6):669-672. PMC: 7992601. DOI: 10.5021/ad.2019.31.6.669. View

Copeland L, Sneige N, Gershenson D, Saul P, Stringer C, Seski J . Adenoid cystic carcinoma of Bartholin gland. Obstet Gynecol. 1986; 67(1):115-20. View

Kontos M, Fentiman I . Adenoid cystic carcinoma of the breast. Int J Clin Pract. 2003; 57(8):669-72. View

10.

Johnson L, Nair R, Sambasivan S, Mony R, Gangadharan J, Kumar A . Adenoid Cystic Carcinoma of Vulva-11 Years' Single-Institution Experience. J Obstet Gynaecol India. 2017; 67(3):196-201. PMC: 5425633. DOI: 10.1007/s13224-016-0935-6. View

11.

Krunic A, Kim S, Medenica M, Laumann A, Soltani K, Shaw J . Recurrent adenoid cystic carcinoma of the scalp treated with mohs micrographic surgery. Dermatol Surg. 2003; 29(6):647-9. DOI: 10.1046/j.1524-4725.2003.29155.x. View

12.

Chen S, Huang S, Ho V, Chuang W, Chan K . Clinical characteristics and treatment outcome of adenoid cystic carcinoma in the external auditory canal. Biomed J. 2020; 43(2):189-194. PMC: 7283548. DOI: 10.1016/j.bj.2019.07.005. View

13.

Hou J, Wu L, Zhang H, Lv N, Huang Y, Yu G . Clinicopathologic characteristics of 12 patients with vulvar sweat gland carcinoma. Int J Gynecol Cancer. 2010; 20(5):874-8. DOI: 10.1111/IGC.0b013e3181e1c167. View

14.

Gualdi G, Monari P, Calzavara-Pinton P, Farisoglio C, Ginani A, Catrani S . Early cutaneous metastasis of adenoid cystic carcinoma of the salivary gland. Cutis. 2014; 93(6):E16-8. View

15.

Tonev I, Pirgova Y, Conev N . Primary Adenoid Cystic Carcinoma of the Skin with Multiple Local Recurrences. Case Rep Oncol. 2015; 8(2):251-5. PMC: 4478305. DOI: 10.1159/000431082. View

16.

Naylor E, Sarkar P, Perlis C, Giri D, Gnepp D, Robinson-Bostom L . Primary cutaneous adenoid cystic carcinoma. J Am Acad Dermatol. 2008; 58(4):636-41. DOI: 10.1016/j.jaad.2007.12.005. View

17.

Dantis K, Ramchandani R, Sahu S, Singh V, Dasgupta S . Primary Cutaneous Adenoid Cystic Carcinoma Of The Chest Wall With Axillary Lymph Node Metastases And Its Management: A Case Report. Port J Card Thorac Vasc Surg. 2023; 30(2):51-54. DOI: 10.48729/pjctvs.293. View

18.

Hatfield T, Wilkinson S, Nijim H . Primary cutaneous adenoid cystic carcinoma of the neck presenting as a rapidly growing posterior triangle neck mass. BMJ Case Rep. 2022; 15(11). PMC: 9693883. DOI: 10.1136/bcr-2022-251436. View

19.

Temnithikul B, Rungrunanghiranya S, Limtanyakul P, Jerasuthat S, Paige D . Primary cutaneous adenoid cystic carcinoma of the scalp: A case report, immunohistochemistry and review of the literature. Skin Health Dis. 2022; 2(2):e118. PMC: 9168016. DOI: 10.1002/ski2.118. View

20.

Chesser R, Bertler D, Fitzpatrick J, Mellette J . Primary cutaneous adenoid cystic carcinoma treated with Mohs micrographic surgery toluidine blue technique. J Dermatol Surg Oncol. 1992; 18(3):175-6. DOI: 10.1111/j.1524-4725.1992.tb02794.x. View