Identifying Key Blood Markers for Bacteremia in Elderly Patients: Insights into Bacterial Pathogens

Overview

Journal Front Cell Infect Microbiol

Date 2025 Jan 31

PMID 39885965

Authors

Shi-Yan Zhang

Ying Zhuo

Bu-Ren Li

Ying-Ying Jiang

Jie Zhang

Na Cai

Lin Yang

Affiliations

Soon will be listed here.

Abstract

Background: This study aimed to assess the distribution of bacteremia pathogens in elderly patients, examine the impact of gender on pathogen distribution, and evaluate the predictive value of routine blood parameters for diagnosing bacteremia.

Methods: A retrospective analysis was conducted on 151 elderly patients (≥60 years old) admitted to Fuding Hospital, Fujian University of Traditional Chinese Medicine between October 2022 and June 2023. Comprehensive routine blood tests and blood cultures were performed. The diagnostic efficacy of routine blood parameters, including white blood cell (WBC), neutrophil-to-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red blood cell distribution width (RDW), was evaluated using receive operating characteristic (ROC) curve analysis. Patients were categorized into either the culture-positive group (82 cases) or the culture-negative group (69 cases) according to blood culture results.

Results: No significant differences in age and gender were found between the culture-positive and culture-negative groups. The primary bacterial pathogens of bacteremia in the elderly were , and . Elderly female patients demonstrated a significantly higher culture positivity rate for compared to their male counterparts ( = 0.021). The areas under the ROC curve (AUC) for the four parameters were as follows: WBC, 0.851 (95% confidence interval (CI) 0.790 - 0.912); NLR, 0.919 (95% CI 0.875 - 0.963); PLR, 0.609 (95% CI 0.518 - 0.700); and RDW was 0.626 (95% CI 0.563 - 0.717).

Conclusions: was identified as the predominant pathogenic microorganism causing bacteremia in the elderly, with a significantly higher culture positivity rate among female patients. Routine blood parameters (WBC, NLR, PLR, and RDW) demonstrated a predictive potential for diagnosing bacteremia in elderly patients.

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