The Link Between Ferroptosis and Autophagy in Myocardial Ischemia/reperfusion Injury: New Directions for Therapy

Overview

Journal J Cardiovasc Transl Res

Publisher Springer

Date 2025 Jan 30

PMID 39885084

Authors

Xiaoting Yang

Hui Wu

Di Liu

Gang Zhou

Dong Zhang

Qingzhuo Yang

Yanfang Liu

Yi Li

Affiliations

Soon will be listed here.

Abstract

Myocardial ischemia/reperfusion (I/R)-induced cell death, such as autophagy and ferroptosis, is a major contributor to cardiac injury. Regulating cell death may be key to mitigating myocardial ischemia/reperfusion injury (MI/RI). Autophagy is a crucial physiological process involving cellular self-digestion and compensation, responsible for degrading excess or malfunctioning long-lived proteins and organelles. During MI/RI, autophagy plays both "survival" and "death" roles. A growing body of research indicates that ferroptosis is a type of autophagy-dependent cell death. This article provides a comprehensive review of the functions of autophagy and ferroptosis in MI/RI, as well as the molecules mediating their interaction. Understanding the link between autophagy and ferroptosis may offer new therapeutic directions for MI/RI, bearing significant clinical implications.

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