Defense Guard: Strategies of Plants in the Fight Against Cadmium Stress

Overview

Journal Adv Biotechnol (Singap)

Date 2025 Jan 30

PMID 39883385

Authors

Qian-Hui Zhang

Yi-Qi Chen

Zhen-Bang Li

Xuan-Tong Tan

Guo-Rong Xin

Chun-Tao He

Affiliations

Soon will be listed here.

Abstract

Soil Cadmium (Cd) contamination is a worldwide problem with negative impacts on human health. Cultivating the Cd-Pollution Safety Cultivar (Cd-PSC) with lower Cd accumulation in edible parts of plants is an environmentally friendly approach to ensure food security with wide application prospects. Specialized mechanisms have been addressed for Cd accumulation in crops. This review provides an extensive generality of molecular regulation mechanisms involved in Cd absorption, transport, detoxification, and tolerance in plants, highlighting key aspects of rhizosphere, apoplast barrier, Cd uptake, transfer, and cellular repair strategies under Cd stress. Additionally, we summarize the possible approaches for lowering the Cd accumulation crops, including molecular-assistant breeding, applying chemical materials, and microbial strategy to decrease Cd content in edible parts and improve Cd tolerance of crops under Cd stress. This review would provide valuable insights for cultivating low Cd accumulated crop cultivars, ultimately contributing to food safety.

References

Wang L, Li R, Yan X, Liang X, Sun Y, Xu Y . Pivotal role for root cell wall polysaccharides in cultivar-dependent cadmium accumulation in Brassica chinensis L. Ecotoxicol Environ Saf. 2020; 194:110369. DOI: 10.1016/j.ecoenv.2020.110369. View

Hu J, Chen G, Xu K, Wang J . Cadmium in Cereal Crops: Uptake and Transport Mechanisms and Minimizing Strategies. J Agric Food Chem. 2022; 70(20):5961-5974. DOI: 10.1021/acs.jafc.1c07896. View

Zhang H, Zhu J, Gong Z, Zhu J . Abiotic stress responses in plants. Nat Rev Genet. 2021; 23(2):104-119. DOI: 10.1038/s41576-021-00413-0. View

Wang L, Lin B, Wu L, Pan P, Liu B, Li R . Antagonistic effect of polystyrene nanoplastics on cadmium toxicity to maize (Zea mays L.). Chemosphere. 2022; 307(Pt 1):135714. DOI: 10.1016/j.chemosphere.2022.135714. View

Nadgorska-Socha A, Kafel A, Kandziora-Ciupa M, Gospodarek J, Zawisza-Raszka A . Accumulation of heavy metals and antioxidant responses in Vicia faba plants grown on monometallic contaminated soil. Environ Sci Pollut Res Int. 2012; 20(2):1124-34. PMC: 3555243. DOI: 10.1007/s11356-012-1191-7. View

Sharma S, Kaur I, Nagpal A . Contamination of rice crop with potentially toxic elements and associated human health risks-a review. Environ Sci Pollut Res Int. 2021; 28(10):12282-12299. DOI: 10.1007/s11356-020-11696-x. View

Yang H, Yu H, Wu Y, Huang H, Zhang X, Ye D . Nitric oxide amplifies cadmium binding in root cell wall of a high cadmium-accumulating rice (Oryza sativa L.) line by promoting hemicellulose synthesis and pectin demethylesterification. Ecotoxicol Environ Saf. 2022; 234:113404. DOI: 10.1016/j.ecoenv.2022.113404. View

Soni S, Jha A, Dubey R, Sharma P . Mitigating cadmium accumulation and toxicity in plants: The promising role of nanoparticles. Sci Total Environ. 2023; 912:168826. DOI: 10.1016/j.scitotenv.2023.168826. View

Yan H, Xu W, Xie J, Gao Y, Wu L, Sun L . Variation of a major facilitator superfamily gene contributes to differential cadmium accumulation between rice subspecies. Nat Commun. 2019; 10(1):2562. PMC: 6561962. DOI: 10.1038/s41467-019-10544-y. View

10.

Wu D, Yamaji N, Yamane M, Kashino-Fujii M, Sato K, Ma J . The HvNramp5 Transporter Mediates Uptake of Cadmium and Manganese, But Not Iron. Plant Physiol. 2016; 172(3):1899-1910. PMC: 5100758. DOI: 10.1104/pp.16.01189. View

11.

Uraguchi S, Kamiya T, Clemens S, Fujiwara T . Characterization of OsLCT1, a cadmium transporter from indica rice (Oryza sativa). Physiol Plant. 2014; 151(3):339-47. DOI: 10.1111/ppl.12189. View

12.

Ozturk M, Metin M, Altay V, De Filippis L, Turkyilmaz Unal B, Khursheed A . Molecular Biology of Cadmium Toxicity in Saccharomyces cerevisiae. Biol Trace Elem Res. 2021; 199(12):4832-4846. DOI: 10.1007/s12011-021-02584-7. View

13.

Li Y, Ding L, Zhou M, Chen Z, Ding Y, Zhu C . Transcriptional Regulatory Network of Plant Cadmium Stress Response. Int J Mol Sci. 2023; 24(5). PMC: 10001906. DOI: 10.3390/ijms24054378. View

14.

Tao J, Lu L . Advances in Genes-Encoding Transporters for Cadmium Uptake, Translocation, and Accumulation in Plants. Toxics. 2022; 10(8). PMC: 9332107. DOI: 10.3390/toxics10080411. View

15.

Takahashi R, Ishimaru Y, Shimo H, Ogo Y, Senoura T, K Nishizawa N . The OsHMA2 transporter is involved in root-to-shoot translocation of Zn and Cd in rice. Plant Cell Environ. 2012; 35(11):1948-57. DOI: 10.1111/j.1365-3040.2012.02527.x. View

16.

Yang Z, Yang F, Liu J, Wu H, Yang H, Shi Y . Heavy metal transporters: Functional mechanisms, regulation, and application in phytoremediation. Sci Total Environ. 2021; 809:151099. DOI: 10.1016/j.scitotenv.2021.151099. View

17.

Sun C, Yang M, Li Y, Tian J, Zhang Y, Liang L . Comprehensive analysis of variation of cadmium accumulation in rice and detection of a new weak allele of OsHMA3. J Exp Bot. 2019; 70(21):6389-6400. PMC: 6859722. DOI: 10.1093/jxb/erz400. View

18.

Ueno D, Yamaji N, Kono I, Huang C, Ando T, Yano M . Gene limiting cadmium accumulation in rice. Proc Natl Acad Sci U S A. 2010; 107(38):16500-5. PMC: 2944702. DOI: 10.1073/pnas.1005396107. View

19.

Hussain B, Li J, Ma Y, Tahir N, Ullah A . Effects of Fe and Mn cations on Cd uptake by rice plant in hydroponic culture experiment. PLoS One. 2020; 15(12):e0243174. PMC: 7728178. DOI: 10.1371/journal.pone.0243174. View

20.

Tang L, Mao B, Li Y, Lv Q, Zhang L, Chen C . Knockout of OsNramp5 using the CRISPR/Cas9 system produces low Cd-accumulating indica rice without compromising yield. Sci Rep. 2017; 7(1):14438. PMC: 5663754. DOI: 10.1038/s41598-017-14832-9. View