Hydroxysafflor Yellow A: a Natural Pigment with Potential Anticancer Therapeutic Effect

Overview

Journal Front Pharmacol

Date 2025 Jan 29

PMID 39877386

Authors

Yuhan Wang

Junsha An

Jianbo Zhou

Liming Chang

Quan Zhang

Fu Peng

Affiliations

Soon will be listed here.

Abstract

Hydroxysafflor yellow A (HSYA), a natural pigment with a chalcone structure extracted from (Safflower), has been widely proven to have good efficacy on cardiovascular diseases, atherosclerosis, cancer, and diabetes. However, no study has reported on the anticancer mechanisms of Hydroxysafflor yellow A (HSYA), a principal bioactive compound in safflower. This review discusses recent developments in the physicochemical properties and sources, pharmacological effects and mechanisms, pharmacokinetic progress, and safety of HSYA, focusing on the involvement of HSYA in the regulation of related pathways and mechanisms of apoptosis, autophagy, and the tumor immune microenvironment in a variety of cancers. This can serve as a theoretical basis for further research and development of HSYA, with insights into the mechanisms of anticancer signaling pathways.

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PMID: 39825917 DOI: 10.1007/s00284-025-04064-w.

References

Jin M, Wu Y, Wang L, Zang B, Tan L . Hydroxysafflor Yellow A Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice. Phytother Res. 2016; 30(4):577-87. DOI: 10.1002/ptr.5560. View

Chen Z, Liu L, Liu Y, Wang S, Zhang S, Dong R . Hydroxysafflor yellow A induces autophagy in human liver cancer cells by regulating Beclin 1 and ERK expression. Exp Ther Med. 2020; 19(4):2989-2996. PMC: 7086224. DOI: 10.3892/etm.2020.8552. View

Fan G, Li F, Wang P, Jin X, Liu R . Natural-Product-Mediated Autophagy in the Treatment of Various Liver Diseases. Int J Mol Sci. 2022; 23(23). PMC: 9739742. DOI: 10.3390/ijms232315109. View

Xue X, Deng Y, Wang J, Zhou M, Liao L, Wang C . Hydroxysafflor yellow A, a natural compound from Carthamus tinctorius L with good effect of alleviating atherosclerosis. Phytomedicine. 2021; 91:153694. DOI: 10.1016/j.phymed.2021.153694. View

Lv L, Tong C, Lv Q, Tang X, Li L, Fang Q . Enhanced absorption of hydroxysafflor yellow A using a self-double-emulsifying drug delivery system: in vitro and in vivo studies. Int J Nanomedicine. 2012; 7:4099-107. PMC: 3415323. DOI: 10.2147/IJN.S33398. View

Han M, Li S, Fan H, An J, Peng C, Peng F . Regulated cell death in glioma: promising targets for natural small-molecule compounds. Front Oncol. 2024; 14:1273841. PMC: 10830839. DOI: 10.3389/fonc.2024.1273841. View

Su D, Lv C . Hydroxysafflor yellow A inhibits the proliferation, migration, and invasion of colorectal cancer cells through the PPARγ/PTEN/Akt signaling pathway. Bioengineered. 2021; 12(2):11533-11543. PMC: 8810180. DOI: 10.1080/21655979.2021.2009965. View

Ming M, He Y . PTEN in DNA damage repair. Cancer Lett. 2012; 319(2):125-129. PMC: 3326178. DOI: 10.1016/j.canlet.2012.01.003. View

Rodriguez-Amaya D . Update on natural food pigments - A mini-review on carotenoids, anthocyanins, and betalains. Food Res Int. 2019; 124:200-205. DOI: 10.1016/j.foodres.2018.05.028. View

10.

Li T, Zhang W, Hu E, Sun Z, Li P, Yu Z . Integrated metabolomics and network pharmacology to reveal the mechanisms of hydroxysafflor yellow A against acute traumatic brain injury. Comput Struct Biotechnol J. 2021; 19:1002-1013. PMC: 7868816. DOI: 10.1016/j.csbj.2021.01.033. View

11.

Pan L, Peng C, Wang L, Li L, Huang S, Fei C . Network pharmacology and experimental validation-based approach to understand the effect and mechanism of Taohong Siwu Decoction against ischemic stroke. J Ethnopharmacol. 2022; 294:115339. DOI: 10.1016/j.jep.2022.115339. View

12.

Lopes L . Overcoming the cutaneous barrier with microemulsions. Pharmaceutics. 2014; 6(1):52-77. PMC: 3978525. DOI: 10.3390/pharmaceutics6010052. View

13.

Amaravadi R, Kimmelman A, White E . Recent insights into the function of autophagy in cancer. Genes Dev. 2016; 30(17):1913-30. PMC: 5066235. DOI: 10.1101/gad.287524.116. View

14.

Wu X, Cai X, Ai J, Zhang C, Liu N, Gao W . Extraction, Structures, Bioactivities and Structure-Function Analysis of the Polysaccharides From Safflower ( L.). Front Pharmacol. 2021; 12:767947. PMC: 8563581. DOI: 10.3389/fphar.2021.767947. View

15.

Wang L, Feng J, Hu K . [Progress in regulation effect of aromatic refreshing traditional Chinese medicine on BBB permeability and its mechanism]. Zhongguo Zhong Yao Za Zhi. 2014; 39(6):949-54. View

16.

Lu K, Chang J, Parachoniak C, Pandika M, Aghi M, Meyronet D . VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex. Cancer Cell. 2012; 22(1):21-35. PMC: 4068350. DOI: 10.1016/j.ccr.2012.05.037. View

17.

Ruibin J, Bo J, Danying W, Jianguo F, Linhui G . Cardamonin induces G2/M phase arrest and apoptosis through inhibition of NF-κB and mTOR pathways in ovarian cancer. Aging (Albany NY). 2020; 12(24):25730-25743. PMC: 7803546. DOI: 10.18632/aging.104184. View

18.

Chen X, Wang Y, Zhang L, Gao Y . Hydroxysafflor Yellow A of Carthamus Tinctorius L., Represses the Malignant Development of Esophageal Cancer Cells via Regulating NF-κB Signaling Pathway. Cell Biochem Biophys. 2020; 78(4):511-520. DOI: 10.1007/s12013-020-00934-1. View

19.

Zhang J, Li J, Song H, Xiong Y, Liu D, Bai X . Hydroxysafflor yellow A suppresses angiogenesis of hepatocellular carcinoma through inhibition of p38 MAPK phosphorylation. Biomed Pharmacother. 2018; 109:806-814. DOI: 10.1016/j.biopha.2018.09.086. View

20.

Szuster-Ciesielska A, Mizerska-Dudka M, Daniluk J, Kandefer-Szerszen M . Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress. J Gastroenterol. 2012; 48(2):222-37. PMC: 3575555. DOI: 10.1007/s00535-012-0619-7. View