Prognostic Implication of Right Ventricular-pulmonary Artery Coupling in Valvular Heart Disease

Overview

Journal Front Cardiovasc Med

Date 2025 Jan 29

PMID 39877024

Authors

Zhenni Wu

Mingxing Xie

Li Zhang

Qing He

Lang Gao

Mengmeng Ji

Yixia Lin

Yuman Li

Affiliations

Soon will be listed here.

Abstract

Valvular heart disease (VHD) leading to inadequate hemodynamic circulation is a major cause of cardiovascular morbidity and mortality worldwide. Right ventricular-pulmonary artery (RV-PA) coupling integrates the ability of RV contractility to adapt to increased pulmonary arterial afterload. If the right ventricle cannot adapt to the elevated afterload by increasing its contractile function, RV-PA uncoupling occurs. RV-PA uncoupling has been shown to be associated with poor outcomes in VHD. This review summarizes the prognostic significance of RV-PA coupling in patients with VHD.

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