Precision Oncology: The Role of Minimally-invasive Ablation Therapy in the Management of Solid Organ Tumors

Overview

Journal World J Radiol

Publisher Baishideng Publishing Group

Date 2025 Jan 29

PMID 39876886

Authors

Farbod Fazlollahi

Mina S Makary

Affiliations

Soon will be listed here.

Abstract

Solid organ tumors present a significant healthcare challenge, both economically and logistically, due to their high incidence and treatment complexity. In 2023, out of the 1.9 million new cancer cases in the United States, over 73% were solid organ tumors. Ablative therapies offer minimally invasive solutions for malignant tissue destruction , often with reduced cost and morbidity compared to surgical resection. This review examines the current Food and Drug Administration-approved locoregional ablative therapies (radiofrequency, microwave, cryogenic, high-intensity focused ultrasound, histotripsy) and their evolving role in cancer care. Data were collected through a comprehensive survey of the PubMed-indexed literature on tumor ablation techniques, their clinical indications, and outcomes. Over time, emerging clinical data will help establish these therapies as the standard of care in solid organ tumor treatment, supported by improved long-term outcomes and progression-free survival.

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