Impact of Diffuse Idiopathic Skeletal Hyperostosis on Quality of Life and Locomotive Syndrome in Community-dwelling Older Adults: the Yakumo Study

Overview

Journal Sci Rep

Date 2025 Jan 28

PMID 39875502

Authors

Kazuma Ohshima

Hiroaki Nakashima

Naoki Segi

Sadayuki Ito

Jun Ouchida

Yasuhiko Takegami

Shinya Ishizuka

Ippei Yamauchi

Yukiharu Hasegawa

Kenta Murotani

Shiro Imagama

Affiliations

Soon will be listed here.

Abstract

Diffuse idiopathic skeletal hyperostosis (DISH) is a common disease in older adults that causes extensive spinal ankylosis. However, its impact on quality of life (QOL) and locomotive syndrome (LS) remains unknown. Thus, we aimed to evaluate the DISH effect on QOL and LS in community-dwelling middle-aged and older adults. Data of community volunteers who attended a health checkup in 2018-2019 were assessed. A total of 455 subjects were included. Whole spine lateral radiographs were obtained to detect DISH according to the Resnik criteria. QOL was evaluated using SF-36 and EQ5D HUSV. LS was evaluated using the stand-up and two-step tests and GLFS-25. Multivariate regression analysis was performed, adjusting for sex, age, body mass index, and knee osteoarthritis. Additionally, a sex-stratified analysis was performed. DISH was detected in 83 (18.2%) participants. Multivariate analysis demonstrated that DISH was significantly associated with low EQ5D HSUV. Multivariate analysis in men demonstrated that DISH was associated with low PCS, low EQ5D HSUV, high LS stage. Multivariate analysis in women demonstrated that DISH was not associated with any QOL or LS. DISH may be associated with a poor QOL. Additionally, DISH is more common and produces a greater clinical impact in men than in women.

References

Yoshimura N . [Locomotive syndrome]. Nihon Rinsho. 2014; 72(4):730-3. View

Singh J, Strand V . Spondyloarthritis is associated with poor function and physical health-related quality of life. J Rheumatol. 2009; 36(5):1012-20. PMC: 2951477. DOI: 10.3899/jrheum.081015. View

Ohshima K, Nakashima H, Segi N, Ito S, Ouchida J, Takegami Y . The prevalence and characteristics of diffuse idiopathic skeletal hyperostosis in the community-living middle-aged and elderly population: The Yakumo study. J Orthop Sci. 2023; 29(6):1346-1352. DOI: 10.1016/j.jos.2023.10.005. View

Kuperus J, Mohamed Hoesein F, de Jong P, Verlaan J . Diffuse idiopathic skeletal hyperostosis: Etiology and clinical relevance. Best Pract Res Clin Rheumatol. 2020; 34(3):101527. DOI: 10.1016/j.berh.2020.101527. View

Kellgren J, Lawrence J . Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957; 16(4):494-502. PMC: 1006995. DOI: 10.1136/ard.16.4.494. View

Resnick D, SHAUL S, Robins J . Diffuse idiopathic skeletal hyperostosis (DISH): Forestier's disease with extraspinal manifestations. Radiology. 1975; 115(3):513-24. DOI: 10.1148/15.3.513. View

Mata S, Fortin P, Fitzcharles M, Starr M, Joseph L, Watts C . A controlled study of diffuse idiopathic skeletal hyperostosis. Clinical features and functional status. Medicine (Baltimore). 1997; 76(2):104-17. DOI: 10.1097/00005792-199703000-00003. View

Forestier J, ROTES-QUEROL J . Senile ankylosing hyperostosis of the spine. Ann Rheum Dis. 1950; 9(4):321-30. PMC: 1011670. DOI: 10.1136/ard.9.4.321. View

Hoogeboom T, den Broeder A, de Bie R, van den Ende C . Longitudinal impact of joint pain comorbidity on quality of life and activity levels in knee osteoarthritis: data from the Osteoarthritis Initiative. Rheumatology (Oxford). 2012; 52(3):543-6. PMC: 3716330. DOI: 10.1093/rheumatology/kes314. View

10.

Ishibashi H . Locomotive syndrome in Japan. Osteoporos Sarcopenia. 2019; 4(3):86-94. PMC: 6362958. DOI: 10.1016/j.afos.2018.09.004. View

11.

Bijlsma A, Meskers C, van den Eshof N, Westendorp R, Sipila S, Stenroth L . Diagnostic criteria for sarcopenia and physical performance. Age (Dordr). 2013; 36(1):275-85. PMC: 3889901. DOI: 10.1007/s11357-013-9556-5. View

12.

Banno T, Togawa D, Hasegawa T, Yamato Y, Yoshida G, Kobayashi S . The controlled study of diffuse idiopathic skeletal hyperostosis for the assessment of physical function in elderly populations. J Orthop Sci. 2018; 23(6):929-934. DOI: 10.1016/j.jos.2018.07.017. View

13.

Katzman W, Huang M, Kritz-Silverstein D, Barrett-Connor E, Kado D . Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Impaired Physical Function: The Rancho Bernardo Study. J Am Geriatr Soc. 2017; 65(7):1476-1481. PMC: 5507717. DOI: 10.1111/jgs.14810. View

14.

Arbex M, Frazao Okazaki J, Brandao Tavares D, Figueiredo Bersani A, Santos F . Locomotive Syndrome is associated with chronic pain and poor quality of life in Brazilian oldest old: LOCOMOV Project. J Orthop Sci. 2020; 26(1):162-166. DOI: 10.1016/j.jos.2020.02.007. View

15.

Soulard J, Vaillant J, Agier C, Vuillerme N . Gait characteristics in patients with ankylosing spondylitis: a systematic review. Clin Exp Rheumatol. 2020; 39(1):173-186. DOI: 10.55563/clinexprheumatol/le3bmj. View

16.

Imagama S, Ando K, Kobayashi K, Machino M, Tanaka S, Morozumi M . Differences of locomotive syndrome and frailty in community-dwelling middle-aged and elderly people: Pain, osteoarthritis, spinal alignment, body balance, and quality of life. Mod Rheumatol. 2019; 30(5):921-929. DOI: 10.1080/14397595.2019.1665616. View

17.

Ohsawa T, Yanagisawa S, Shiozawa H, Omodaka T, Saito K, Kitagawa T . Relationship between knee osteoarthritis and the locomotive syndrome risk tests: A cross-sectional study. J Orthop Sci. 2016; 21(4):512-516. DOI: 10.1016/j.jos.2016.03.011. View

18.

Law L, Beckman Rehnman J, Deminger A, Klingberg E, Jacobsson L, Forsblad-dElia H . Factors related to health-related quality of life in ankylosing spondylitis, overall and stratified by sex. Arthritis Res Ther. 2018; 20(1):284. PMC: 6307231. DOI: 10.1186/s13075-018-1784-8. View

19.

Kagotani R, Yoshida M, Muraki S, Oka H, Hashizume H, Yamada H . Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) of the whole spine and its association with lumbar spondylosis and knee osteoarthritis: the ROAD study. J Bone Miner Metab. 2014; 33(2):221-9. DOI: 10.1007/s00774-014-0583-9. View

20.

Stovall R, van der Horst-Bruinsma I, Liu S, Rusman T, Gensler L . Sexual dimorphism in the prevalence, manifestation and outcomes of axial spondyloarthritis. Nat Rev Rheumatol. 2022; 18(11):657-669. DOI: 10.1038/s41584-022-00833-0. View