Effect of a Modified Methyl Methacrylate-p-styrene Sulfonic Acid Copolymer-based Gel Desensitizer on Dentin Permeability and Tubule Occlusion in Human Dentin

Overview

Journal J Dent Sci

Date 2025 Jan 28

PMID 39873090

Authors

Athimas Chatanan

Kanittha Kijsamanmith

Varunee Kerdvongbundit

Thanwarat Aroonrangsee

Noppakun Vongsavan

Affiliations

Soon will be listed here.

Abstract

Background/purpose: Tubular occlusion is an effective method to treat dentin hypersensitivity. This study aimed to determine the effect of a modified methyl methacrylate-p-styrene sulfonic acid copolymer-based gel desensitizer on dentin permeability and tubule occlusion in extracted human premolars.

Materials And Methods: Hydraulic conductance (HC) measurement (n = 50) and scanning electron microscopy (SEM; n = 64) were performed. Tooth specimens were divided into 6 groups and treated with: G1, distilled water for 30 s; G2, distilled water for 5 min; G3, gel desensitizer for 30 s; G4, gel desensitizer for 5 min; G5, 3% potassium oxalate for 30 s; G6, 3% potassium oxalate for 5 min. HC of dentin were measured before and after 30 s-etching with 35% phosphoric acid, at 0, 30, 60 min after group treatment and after 5-min acid challenge with 6% citric acid. The degree of tubule occlusion and the penetration depth of each agent were also determined. ANOVA and multiple comparison tests were used for data analysis.

Results: G3, G4, G5 and G6 significantly decreased in HC after group treatment every observation period, compared to after acid-etching ( < 0.001), and had 100% degree of tubule occlusion with penetration depth about 7.62, 7.94, 8.59 and 8.66 μm, respectively. However, G6 showed the greatest reduction in HC ( < 0.05).

Conclusion: Gel desensitizer treatment, for only 30 s, could reduce dentin permeability and completely occlude the dentinal tubules, even though after acid challenge. However, 5-min treatment with potassium oxalate showed the greatest decrease in dentin permeability.

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