Splicing Factor PRP-19 Regulates Mitochondrial Stress Response

Overview

Journal Life Metab

Publisher Oxford University Press

Date 2025 Jan 28

PMID 39872685

Authors

Peixue Xia

Liankui Zhou

Jialiang Guan

Wanqiu Ding

Ying Liu

Affiliations

Soon will be listed here.

Abstract

Animals respond to mitochondrial perturbation by activating the mitochondrial unfolded protein response (UPR) to induce the transcription of mitochondrial stress response genes. In , activation of UPR allows the animals to maintain organismal homeostasis, activate the innate immune response, and promote lifespan extension. Here, we show that splicing factors such as Precursor RNA processing 19 (PRP-19) are required for the induction of UPR in . PRP-19 also modulates mitochondrial perturbation-induced innate immune response and lifespan extension. Knockdown of PRP-19 in mammalian cells suppresses UPR activation and disrupts the mitochondrial network. These findings reveal an evolutionarily conserved mechanism that maintains mitochondrial homeostasis and controls innate immunity and lifespan through splicing factors.

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