Despicable Role of Epithelial-mesenchymal Transition in Breast Cancer Metastasis: Exhibiting Restorative Regimens

Overview

Journal Cancer Pathog Ther

Date 2025 Jan 28

PMID 39872366

Authors

Paras Famta

Saurabh Shah

Biswajit Dey

Kondasingh Charan Kumar

Deepkumar Bagasariya

Ganesh Vambhurkar

Giriraj Pandey

Anamika Sharma

Dadi A Srinivasarao

Rahul Kumar

Santosh Kumar Guru

Rajeev Singh Raghuvanshi

Saurabh Srivastava

Affiliations

Soon will be listed here.

Abstract

Breast cancer (BC) is the most prevalent cancer in women globally. Anti-cancer advancements have enabled the killing of BC cells through various therapies; however, cancer relapse is still a major limitation and decreases patient survival and quality of life. Epithelial-to-mesenchymal transition (EMT) is responsible for tumor relapse in several cancers. This highly regulated event causes phenotypic, genetic, and epigenetic changes in the tumor microenvironment (TME). This review summarizes the recent advancements regarding EMT using de-differentiation and partial EMT theories. We extensively review the mechanistic pathways, TME components, and various anti-cancer adjuvant and neo-adjuvant therapies responsible for triggering EMT in BC tumors. Information regarding essential clinical studies and trials is also discussed. Furthermore, we also highlight the recent strategies targeting various EMT pathways. This review provides a holistic picture of BC biology, molecular pathways, and recent advances in therapeutic strategies.

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