Long-term Burden of Body Mass Index Since Childhood and Impaired Physical Performance in Midlife

Overview

Journal Pediatr Res

Date 2025 Jan 27

PMID 39870772

Authors

Tingting Du

Lydia Bazzano

Affiliations

Soon will be listed here.

Abstract

Background: The impact of long-term burden of body mass index (BMI) since childhood on physical performance in midlife remains unclear. We aimed to investigate the association between cumulative exposure to BMI since childhood and midlife physical performance by using data from the Bogalusa Heart Study (BHS).

Methods: This longitudinal study consisted of 749 participants (aged 37.6 to 56.7 years at follow-up) who had been examined at least four times during childhood, with 39.3 years of follow-up.

Results: BMI in childhood, adulthood, as a cumulative burden of BMI in childhood, or as a cumulative burden from childhood to adulthood were inversely associated with midlife Short Physical Performance Battery (SPPB) scores, 4-m gait speed, and 6-min walking distance. Individuals with higher BMI as adults but not as children did not have lower SPPB scores (OR,1.67; 95% CI, 0.85-3.27), while individuals with consistently high BMI from childhood to adulthood (2.13 1.18-3.82) and individuals with high childhood BMI (2.12 [1.10-4.10]) but low adult BMI had significantly increased risk compared with individuals with low child and low adult BMI.

Conclusion: Cumulative burden of BMI from childhood to midlife associated with worse midlife physical performance. Maintaining a healthy body weight throughout life may play a role in preventing or delaying the onset of functional decline.

Impact: We examined the impact of long-term burden of body mass index (BMI) since childhood on subsequent physical performance in midlife. We found that ①BMI in childhood and cumulative burden of BMI since childhood were associated with poor physical function in midlife; ② Individuals with high childhood BMI but low adult BMI have poor midlife physical performance; ③ Subjects with both high childhood and adulthood BMI have worse midlife physical performance. Our findings have important implications for active monitoring BMI from childhood and turning the focus of functional decline prevention to primary and primordial prevention.

References

Foot D, Lewis R, PEARSON T, Beller G . Demographics and cardiology, 1950-2050. J Am Coll Cardiol. 2000; 35(4):1067-81. DOI: 10.1016/s0735-1097(00)00561-1. View

Guralnik J, Ferrucci L, Simonsick E, Salive M, Wallace R . Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995; 332(9):556-61. PMC: 9828188. DOI: 10.1056/NEJM199503023320902. View

Sergi G, Veronese N, Fontana L, De Rui M, Bolzetta F, Zambon S . Pre-frailty and risk of cardiovascular disease in elderly men and women: the Pro.V.A. study. J Am Coll Cardiol. 2015; 65(10):976-83. DOI: 10.1016/j.jacc.2014.12.040. View

Daviglus M, Liu K, Yan L, Pirzada A, Garside D, Schiffer L . Body mass index in middle age and health-related quality of life in older age: the Chicago heart association detection project in industry study. Arch Intern Med. 2003; 163(20):2448-55. DOI: 10.1001/archinte.163.20.2448. View

Beyer I, Mets T, Bautmans I . Chronic low-grade inflammation and age-related sarcopenia. Curr Opin Clin Nutr Metab Care. 2011; 15(1):12-22. DOI: 10.1097/MCO.0b013e32834dd297. View

Abbatecola A, Paolisso G, Fattoretti P, Evans W, Fiore V, Dicioccio L . Discovering pathways of sarcopenia in older adults: a role for insulin resistance on mitochondria dysfunction. J Nutr Health Aging. 2011; 15(10):890-5. DOI: 10.1007/s12603-011-0366-0. View

Li S, Chen W, Srinivasan S, Bond M, Tang R, Urbina E . Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa Heart Study. JAMA. 2003; 290(17):2271-6. DOI: 10.1001/jama.290.17.2271. View

Li X, Li S, Ulusoy E, Chen W, Srinivasan S, Berenson G . Childhood adiposity as a predictor of cardiac mass in adulthood: the Bogalusa Heart Study. Circulation. 2004; 110(22):3488-92. DOI: 10.1161/01.CIR.0000149713.48317.27. View

Zhang T, Fan B, Li S, Wang X, Kong Y, Bazzano L . Long-Term Adiposity and Midlife Carotid Intima-Media Thickness Are Linked Partly Through Intermediate Risk Factors. Hypertension. 2022; 80(1):160-168. PMC: 9742127. DOI: 10.1161/HYPERTENSIONAHA.122.20217. View

10.

Yan Y, Li S, Guo Y, Fernandez C, Bazzano L, He J . Life-Course Cumulative Burden of Body Mass Index and Blood Pressure on Progression of Left Ventricular Mass and Geometry in Midlife: The Bogalusa Heart Study. Circ Res. 2020; 126(5):633-643. PMC: 7047524. DOI: 10.1161/CIRCRESAHA.119.316045. View

11.

Harville E, Chen W, Guralnik J, Bazzano L . Reproductive history and physical functioning in midlife: The Bogalusa Heart Study. Maturitas. 2018; 109:26-31. PMC: 5819611. DOI: 10.1016/j.maturitas.2017.12.006. View

12.

Veronese N, Berton L, Carraro S, Bolzetta F, De Rui M, Perissinotto E . Effect of oral magnesium supplementation on physical performance in healthy elderly women involved in a weekly exercise program: a randomized controlled trial. Am J Clin Nutr. 2014; 100(3):974-81. DOI: 10.3945/ajcn.113.080168. View

13.

Odden M, Peralta C, Haan M, Covinsky K . Rethinking the association of high blood pressure with mortality in elderly adults: the impact of frailty. Arch Intern Med. 2012; 172(15):1162-8. PMC: 3537835. DOI: 10.1001/archinternmed.2012.2555. View

14.

Bandinelli S, Benvenuti E, Del Lungo I, Baccini M, Benvenuti F, Di Iorio A . Measuring muscular strength of the lower limbs by hand-held dynamometer: a standard protocol. Aging (Milano). 2000; 11(5):287-93. DOI: 10.1007/BF03339802. View

15.

Guyatt G, Sullivan M, Thompson P, Fallen E, Pugsley S, Taylor D . The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure. Can Med Assoc J. 1985; 132(8):919-23. PMC: 1345899. View

16.

Cook N, Rosner B, Chen W, Srinivasan S, Berenson G . Using the area under the curve to reduce measurement error in predicting young adult blood pressure from childhood measures. Stat Med. 2004; 23(22):3421-35. DOI: 10.1002/sim.1921. View

17.

Afilalo J, Alexander K, Mack M, Maurer M, Green P, Allen L . Frailty assessment in the cardiovascular care of older adults. J Am Coll Cardiol. 2013; 63(8):747-62. PMC: 4571179. DOI: 10.1016/j.jacc.2013.09.070. View

18.

Du T, Fernandez C, Barshop R, Guralnik J, Bazzano L . Cardiovascular risk factors from childhood and midlife physical function: The Bogalusa Heart Study. Exp Gerontol. 2020; 136:110947. PMC: 7513196. DOI: 10.1016/j.exger.2020.110947. View

19.

Eriksson J, Osmond C, Perala M, Salonen M, Simonen M, Pohjolainen P . Prenatal and childhood growth and physical performance in old age--findings from the Helsinki Birth Cohort Study 1934-1944. Age (Dordr). 2015; 37(6):108. PMC: 5005845. DOI: 10.1007/s11357-015-9846-1. View

20.

Kuh D, Hardy R, Butterworth S, Okell L, Richards M, Wadsworth M . Developmental origins of midlife physical performance: evidence from a British birth cohort. Am J Epidemiol. 2006; 164(2):110-21. DOI: 10.1093/aje/kwj193. View