Staphylococcus Aureus Blocks Host Autophagy Through CircSyk/miR-5106/Sik3 Axis to Promote Progression of Bone Infection

Overview

Journal PLoS Pathog

Date 2025 Jan 27

PMID 39869636

Authors

Zhihao Chen

Qiyuan Jin

Jinqi Zhong

Zonggang Xie

Qi Chen

Liubing Li

Jijie Li

Chenhao Zhao

Junfeng Wang

Xiaoying Tang

Mingxiao Han

Ru Li

Ziyuan Li

Zelei Tong

Min Wang

Hong Du

Haifang Zhang

Affiliations

Soon will be listed here.

Abstract

With the rapid increase in the number of implant operations, the incidence of bone infections has increased. Methicillin-resistant Staphylococcus aureus (S. aureus) and other emerging fully drug-resistant strains make the management of bone infections even more challenging. Bone infections are mainly caused by S. aureus and require extensive surgical intervention and long-term antibiotic therapy. The host autophagy response is critical to the elimination of S. aureus infections. In this study, we demonstrate that a circular RNA (circRNA), circSyk, is a potential biological target for the treatment of S. aureus-induced bone infection. Most importantly, S. aureus regulates circSyk to block autophagy and promote bone destruction via the circSyk/miR-5106/Sik3 axis in a nonclassical pathway, which is involved in the S. aureus infection process through a competitive endogenous RNA network. In summary, this study proposes a novel perspective on the immune escape of S. aureus in bone infections, based on circRNA.

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