Lipedema: Exploring Pathophysiology and Treatment Strategies - State of the Art

Overview

Journal J Vasc Bras

Date 2025 Jan 27

PMID 39866170

Authors

Fabio Kamamoto

Jaqueline Munaretto Timm Baiocchi

Bernardo Nogueira Batista

Renan Diego Americo Ribeiro

Debora Aparecida Oliveira Modena

Vitor Cervantes Gornati

Affiliations

Soon will be listed here.

Abstract

Lipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.

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