Chronic Endometritis and Antimicrobial Resistance: Towards a Multidrug-Resistant Endometritis? An Expert Opinion

Overview

Journal Microorganisms

Date 2025 Jan 25

PMID 39858965

Authors

Francesco Di Gennaro

Giacomo Guido

Luisa Frallonardo

Laura Pennazzi

Miriana Bevilacqua

Pietro Locantore

Amerigo Vitagliano

Annalisa Saracino

Ettore Cicinelli

Affiliations

Soon will be listed here.

Abstract

Chronic endometritis (CE) is a persistent inflammatory condition of the endometrium characterized by abnormal infiltration of plasma cells into the endometrial stroma. Frequently associated with repeated implantation failure, recurrent pregnancy loss, and infertility, CE significantly impacts women's health, contributing to conditions such as abnormal uterine bleeding and endometriosis. Treatment typically involves antibiotic therapy; however, the efficacy of these treatments is increasingly compromised by the rise of antimicrobial resistance (AMR). This paper examines the critical links between AMR and CE, proposing strategies to enhance clinical management and optimize treatment outcomes.

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