Utilisation of High Molecular Weight and Ultra-High Molecular Weight Hyaluronan in Management of Glioblastoma

Overview

Journal Gels

Date 2025 Jan 24

PMID 39852021

Authors

Alex-Adrian Salagean

Cezara-Anca-Denisa Moldovan

Mark Slevin

Affiliations

Soon will be listed here.

Abstract

HA (hyaluronan) has been considered in recent years as a naturally occurring modifiable gel-like scaffold that has the capability to absorb and release drugs over an extended period of time making it suitable as a potential chemotherapeutic delivery agent. Considering the limited treatment options available in the treatment of glioblastoma, in this review, we discuss the novel utilisation of ultra-high molecular weight HA-originally identified as a mechanism for maintaining longevity in the naked mole-rat-as both a protective and extracellular matrix-optimizing colloidal scaffold, and a means to deliver therapy in resected brain tumours. The unique properties of this unique form of HA cross-linked gel indicate potential future use in the prevention and treatment of both proliferative-based and inflammation-driven disease.

References

Abpeikar Z, Javdani M, Mirzaei S, Alizadeh A, Moradi L, Soleimannejad M . Macroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair. Int J Biol Macromol. 2021; 183:1327-1345. DOI: 10.1016/j.ijbiomac.2021.04.151. View

Moshayedi P, Nih L, Llorente I, Berg A, Cinkornpumin J, Lowry W . Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain. Biomaterials. 2016; 105:145-155. PMC: 5003628. DOI: 10.1016/j.biomaterials.2016.07.028. View

Tan A, Ashley D, Lopez G, Malinzak M, Friedman H, Khasraw M . Management of glioblastoma: State of the art and future directions. CA Cancer J Clin. 2020; 70(4):299-312. DOI: 10.3322/caac.21613. View

Djoudi A, Molina-Pena R, Ferreira N, Ottonelli I, Tosi G, Garcion E . Hyaluronic Acid Scaffolds for Loco-Regional Therapy in Nervous System Related Disorders. Int J Mol Sci. 2022; 23(20). PMC: 9602826. DOI: 10.3390/ijms232012174. View

Agrahari V . The exciting potential of nanotherapy in brain-tumor targeted drug delivery approaches. Neural Regen Res. 2017; 12(2):197-200. PMC: 5361495. DOI: 10.4103/1673-5374.200796. View

Fan S, Zheng Y, Liu X, Fang W, Chen X, Liao W . Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer's disease. Drug Deliv. 2018; 25(1):1091-1102. PMC: 6116673. DOI: 10.1080/10717544.2018.1461955. View

Alsaikhan F, Farhood B . Recent advances on chitosan/hyaluronic acid-based stimuli-responsive hydrogels and composites for cancer treatment: A comprehensive review. Int J Biol Macromol. 2024; 280(Pt 3):135893. DOI: 10.1016/j.ijbiomac.2024.135893. View

Jensen G, Holloway J, Stabenfeldt S . Hyaluronic Acid Biomaterials for Central Nervous System Regenerative Medicine. Cells. 2020; 9(9). PMC: 7565873. DOI: 10.3390/cells9092113. View

Su W, Matsumoto S, Sorg B, Sherman L . Distinct roles for hyaluronan in neural stem cell niches and perineuronal nets. Matrix Biol. 2018; 78-79:272-283. PMC: 6068007. DOI: 10.1016/j.matbio.2018.01.022. View

10.

Lagunas-Rangel F . Naked mole-rat hyaluronan. Biochimie. 2023; 220:58-66. DOI: 10.1016/j.biochi.2023.12.008. View

11.

Kulaberoglu Y, Bhushan B, Hadi F, Chakrabarti S, Khaled W, Rankin K . The material properties of naked mole-rat hyaluronan. Sci Rep. 2019; 9(1):6632. PMC: 6488695. DOI: 10.1038/s41598-019-43194-7. View

12.

Wang Y, Tan H, Hui X . Biomaterial Scaffolds in Regenerative Therapy of the Central Nervous System. Biomed Res Int. 2018; 2018:7848901. PMC: 5899851. DOI: 10.1155/2018/7848901. View

13.

Pibuel M, Poodts D, Molinari Y, Diaz M, Amoia S, Byrne A . The importance of RHAMM in the normal brain and gliomas: physiological and pathological roles. Br J Cancer. 2022; 128(1):12-20. PMC: 9814267. DOI: 10.1038/s41416-022-01999-w. View

14.

Tian X, Azpurua J, Ke Z, Augereau A, Zhang Z, Vijg J . INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform. Proc Natl Acad Sci U S A. 2015; 112(4):1053-8. PMC: 4313802. DOI: 10.1073/pnas.1418203112. View

15.

Seluanov A, Hine C, Azpurua J, Feigenson M, Bozzella M, Mao Z . Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proc Natl Acad Sci U S A. 2009; 106(46):19352-7. PMC: 2780760. DOI: 10.1073/pnas.0905252106. View

16.

Xu Y, Stamenkovic I, Yu Q . CD44 attenuates activation of the hippo signaling pathway and is a prime therapeutic target for glioblastoma. Cancer Res. 2010; 70(6):2455-64. PMC: 2840073. DOI: 10.1158/0008-5472.CAN-09-2505. View

17.

Barbarisi M, Iaffaioli R, Armenia E, Schiavo L, De Sena G, Tafuto S . Novel nanohydrogel of hyaluronic acid loaded with quercetin alone and in combination with temozolomide as new therapeutic tool, CD44 targeted based, of glioblastoma multiforme. J Cell Physiol. 2017; 233(10):6550-6564. DOI: 10.1002/jcp.26238. View

18.

Safarians G, Sohrabi A, Solomon I, Xiao W, Bastola S, Rajput B . Glioblastoma Spheroid Invasion through Soft, Brain-Like Matrices Depends on Hyaluronic Acid-CD44 Interactions. Adv Healthc Mater. 2023; 12(14):e2203143. PMC: 10238626. DOI: 10.1002/adhm.202203143. View

19.

Coulson-Thomas V, Lauer M, Soleman S, Zhao C, Hascall V, Day A . Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Is Constitutively Expressed in Adult Central Nervous System (CNS) and Associated with Astrocyte-mediated Glial Scar Formation following Spinal Cord Injury. J Biol Chem. 2016; 291(38):19939-52. PMC: 5025681. DOI: 10.1074/jbc.M115.710673. View

20.

Lubanska D, Alrashed S, Mason G, Nadeem F, Awada A, DiPasquale M . Impairing proliferation of glioblastoma multiforme with CD44+ selective conjugated polymer nanoparticles. Sci Rep. 2022; 12(1):12078. PMC: 9287456. DOI: 10.1038/s41598-022-15244-0. View