Focal Therapy for Prostate Cancer: Recent Advances and Insights

Overview

Journal Curr Oncol

Publisher MDPI

Date 2025 Jan 24

PMID 39851931

Authors

Francesco Lasorsa

Arianna Biasatti

Angelo Orsini

Gabriele Bignante

Gabriana M Farah

Savio Domenico Pandolfo

Luca Lambertini

Deepika Reddy

Rocco Damiano

Pasquale Ditonno

Giuseppe Lucarelli

Riccardo Autorino

Srinivas Vourganti

Affiliations

Soon will be listed here.

Abstract

Focal therapy has emerged as a balanced middle ground aiming to reduce overtreatment and the risk of progression, as well as patients' distress and anxiety. Focal therapy and partial gland ablation prioritize the precise elimination of the index lesion and a surrounding safety margin to optimize treatment outcomes and lower the risk of residual disease. The paradigm of whole-gland ablation has shifted towards more targeted approaches. Several treatment templates ranging from subtotal and hemiablation to "hockey-stick", quadrant, and even focal lesion ablation have emerged. Many types of energy may be utilized during focal treatment. First, focal therapy can be grossly classified into thermal vs. non-thermal energy. The aim of this non-systematic review is to offer a comprehensive analysis of recently available evidence on focal therapy for PCa.

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