Extracellular Matrix Shapes Cancer Stem Cell Behavior in Breast Cancer: a Mini Review

Overview

Journal Front Immunol

Date 2025 Jan 24

PMID 39850890

Authors

Lei Li

YiDan Tang

Ling Qiu

Zhengrui Li

Ruo Wang

Affiliations

Soon will be listed here.

Abstract

Today, cancer has become one of the leading global tragedies. It occurs when a small number of cells in the body mutate, causing some of them to evade the body's immune system and proliferate uncontrollably. Even more irritating is the fact that patients with cancers frequently relapse after conventional chemotherapy and radiotherapy, leading to additional suffering. Scientists thereby presume that cancer stem cells (CSCs) are the underlying cause of metastasis and recurrence. In recent years, it was shown that not only can chemotherapy and radiotherapy underperform in the treatment of breast cancer, but they can also increase the number of breast cancer stem cells (BCSCs) that transform regular breast cancer cells into their own population. Such data somewhat support the aforementioned hypothesis. Meanwhile, our understanding of the extracellular matrix (ECM) has changed considerably over the last decade. A lot of studies have bit by bit complemented human knowledge regarding how the ECM greatly shapes the behaviors of BCSCs. In this review, we highlighted the influence on BCSCs exerted by different critical components and biochemical properties of ECM.

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References

Ryoo I, Choi B, Ku S, Kwak M . High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance. Redox Biol. 2018; 17:246-258. PMC: 6006726. DOI: 10.1016/j.redox.2018.04.015. View

Morris B, Burkel B, Ponik S, Fan J, Condeelis J, Aguirre-Ghiso J . Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells. EBioMedicine. 2016; 13:146-156. PMC: 5264313. DOI: 10.1016/j.ebiom.2016.10.012. View

Oskarsson T . Extracellular matrix components in breast cancer progression and metastasis. Breast. 2013; 22 Suppl 2:S66-72. DOI: 10.1016/j.breast.2013.07.012. View

Ishihara S, Haga H . Matrix Stiffness Contributes to Cancer Progression by Regulating Transcription Factors. Cancers (Basel). 2022; 14(4). PMC: 8870363. DOI: 10.3390/cancers14041049. View

Chen L, Xiao Z, Meng Y, Zhao Y, Han J, Su G . The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs. Biomaterials. 2011; 33(5):1437-44. DOI: 10.1016/j.biomaterials.2011.10.056. View

Maris P, Blomme A, Palacios A, Costanza B, Bellahcene A, Bianchi E . Asporin Is a Fibroblast-Derived TGF-β1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer. PLoS Med. 2015; 12(9):e1001871. PMC: 4556693. DOI: 10.1371/journal.pmed.1001871. View

Brassart-Pasco S, Brezillon S, Brassart B, Ramont L, Oudart J, Monboisse J . Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression. Front Oncol. 2020; 10:397. PMC: 7174611. DOI: 10.3389/fonc.2020.00397. View

Ye J, Wu D, Wu P, Chen Z, Huang J . The cancer stem cell niche: cross talk between cancer stem cells and their microenvironment. Tumour Biol. 2014; 35(5):3945-51. DOI: 10.1007/s13277-013-1561-x. View

Saha S, Lo P, Duan X, Chen H, Wang Q . Breast tumour initiating cell fate is regulated by microenvironmental cues from an extracellular matrix. Integr Biol (Camb). 2012; 4(8):897-904. DOI: 10.1039/c2ib20034a. View

10.

Sun Y, Kim H, Saw P, Jon S, Moon W . Targeted Therapy for Breast Cancer Stem Cells by Liposomal Delivery of siRNA against Fibronectin EDB. Adv Healthc Mater. 2015; 4(11):1675-80. DOI: 10.1002/adhm.201500190. View

11.

Emens L . Breast Cancer Immunotherapy: Facts and Hopes. Clin Cancer Res. 2017; 24(3):511-520. PMC: 5796849. DOI: 10.1158/1078-0432.CCR-16-3001. View

12.

Arnold K, Opdenaker L, Flynn D, Sims-Mourtada J . Wound healing and cancer stem cells: inflammation as a driver of treatment resistance in breast cancer. Cancer Growth Metastasis. 2015; 8:1-13. PMC: 4315129. DOI: 10.4137/CGM.S11286. View

13.

Zhu J, Wang H, Sun Q, Ji X, Zhu L, Cong Z . Nrf2 is required to maintain the self-renewal of glioma stem cells. BMC Cancer. 2013; 13:380. PMC: 3751732. DOI: 10.1186/1471-2407-13-380. View

14.

Pradella D, Naro C, Sette C, Ghigna C . EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression. Mol Cancer. 2017; 16(1):8. PMC: 5282733. DOI: 10.1186/s12943-016-0579-2. View

15.

Jeter C, Badeaux M, Choy G, Chandra D, Patrawala L, Liu C . Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells. 2009; 27(5):993-1005. PMC: 3327393. DOI: 10.1002/stem.29. View

16.

Nallanthighal S, Heiserman J, Cheon D . Collagen Type XI Alpha 1 (COL11A1): A Novel Biomarker and a Key Player in Cancer. Cancers (Basel). 2021; 13(5). PMC: 7956367. DOI: 10.3390/cancers13050935. View

17.

Kalluri R, Weinberg R . The basics of epithelial-mesenchymal transition. J Clin Invest. 2009; 119(6):1420-8. PMC: 2689101. DOI: 10.1172/JCI39104. View

18.

Jacobs A, Martinez Castaneda-Cruz D, Rose M, Connelly L . Targeted therapy for breast cancer: An overview of drug classes and outcomes. Biochem Pharmacol. 2022; 204:115209. DOI: 10.1016/j.bcp.2022.115209. View

19.

Williams K, Motiani K, Giridhar P, Kasper S . CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches. Exp Biol Med (Maywood). 2013; 238(3):324-38. PMC: 11037417. DOI: 10.1177/1535370213480714. View

20.

Chang C, Goel H, Gao H, Pursell B, Shultz L, Greiner D . A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells. Genes Dev. 2015; 29(1):1-6. PMC: 4281560. DOI: 10.1101/gad.253682.114. View