Unsuspecting Plaque on the Forearm: A Diagnostic Challenge

Overview

Journal Indian Dermatol Online J

Date 2025 Jan 24

PMID 39850702

Authors

Ramith P Shetty

M Ramesh Bhat

Myfanwy Joanne DSouza

Michelle S Fernandes

Affiliations

Soon will be listed here.

Abstract

Microcystic adnexal carcinoma (MAC) is a rare, slow-growing, locally aggressive malignant, and recurring appendageal tumor. Prolonged UV exposure, immunosuppression, and radiotherapy are a few frequently associated risk factors. MAC classically presents as an asymptomatic skin coloured plaque on the face. The key to diagnosis is a deep-sectioned biopsy. Surgical modalities are the first line of treatment.

References

Goldstein D, Barr R, Santa Cruz D . Microcystic adnexal carcinoma: a distinct clinicopathologic entity. Cancer. 1982; 50(3):566-72. DOI: 10.1002/1097-0142(19820801)50:3<566::aid-cncr2820500330>3.0.co;2-q. View

Gordon S, Fischer C, Martin A, Rosman I, Council M . Microcystic Adnexal Carcinoma: A Review of the Literature. Dermatol Surg. 2017; 43(8):1012-1016. DOI: 10.1097/DSS.0000000000001142. View

Rahman J, Tahir M, Arekemase H, Murtazaliev S, Sonawane S . Desmoplastic Trichoepithelioma: Histopathologic and Immunohistochemical Criteria for Differentiation of a Rare Benign Hair Follicle Tumor From Other Cutaneous Adnexal Tumors. Cureus. 2020; 12(8):e9703. PMC: 7486105. DOI: 10.7759/cureus.9703. View

Dores G, Huycke M, Devesa S, Garcia C . Primary cutaneous adenoid cystic carcinoma in the United States: incidence, survival, and associated cancers, 1976 to 2005. J Am Acad Dermatol. 2010; 63(1):71-8. PMC: 2885489. DOI: 10.1016/j.jaad.2009.07.027. View

Worley B, Owen J, Barker C, Behshad R, Bichakjian C, Bolotin D . Evidence-Based Clinical Practice Guidelines for Microcystic Adnexal Carcinoma: Informed by a Systematic Review. JAMA Dermatol. 2019; 155(9):1059-1068. DOI: 10.1001/jamadermatol.2019.1251. View

Wetter R, Goldstein G . Microcystic adnexal carcinoma: a diagnostic and therapeutic challenge. Dermatol Ther. 2008; 21(6):452-8. DOI: 10.1111/j.1529-8019.2008.00246.x. View

Chaudhari S, Mortazie M, Blattner C, Garelik J, Wolff M, Daulat J . Treatments for microcystic adnexal carcinoma--A review. J Dermatolog Treat. 2015; 27(3):278-84. DOI: 10.3109/09546634.2015.1089351. View

Amon G, Liszewski W, Maher I . Epidemiology and Survival of Microcystic Adnexal Carcinoma by Sex in the United States. Dermatol Surg. 2019; 47(1):127-129. DOI: 10.1097/DSS.0000000000002167. View

Sung P, Luger S . Minimal Residual Disease in Acute Myeloid Leukemia. Curr Treat Options Oncol. 2017; 18(1):1. DOI: 10.1007/s11864-017-0447-3. View

Zhang L, Huang X, Zhou T, Cao H . Microcystic adnexal carcinoma: report of rare cases. Biosci Rep. 2020; 40(1). PMC: 6974419. DOI: 10.1042/BSR20191557. View

10.

Friedman P, Friedman R, Jiang S, Nouri K, Amonette R, Robins P . Microcystic adnexal carcinoma: collaborative series review and update. J Am Acad Dermatol. 1999; 41(2 Pt 1):225-31. DOI: 10.1016/s0190-9622(99)70053-8. View

11.

Leboit P, Sexton M . Microcystic adnexal carcinoma of the skin. A reappraisal of the differentiation and differential diagnosis of an underrecognized neoplasm. J Am Acad Dermatol. 1993; 29(4):609-18. DOI: 10.1016/0190-9622(93)70228-l. View

12.

Aslam A . Microcystic Adnexal Carcinoma and a Summary of Other Rare Malignant Adnexal Tumours. Curr Treat Options Oncol. 2017; 18(8):49. DOI: 10.1007/s11864-017-0491-z. View

13.

Saha A, Das N, Gharami R, Chowdhury S, Datta P . A clinico-histopathological study of appendageal skin tumors, affecting head and neck region in patients attending the dermatology opd of a tertiary care centre in eastern India. Indian J Dermatol. 2011; 56(1):33-6. PMC: 3088931. DOI: 10.4103/0019-5154.77548. View