Autoimmune Protocol Diet: A Personalized Elimination Diet for Patients with Autoimmune Diseases

Overview

Journal Metabol Open

Date 2025 Jan 24

PMID 39850611

Authors

Eleni C Pardali

Arriana Gkouvi

Kalliopi K Gkouskou

Anastasios C Manolakis

Christina Tsigalou

Dimitrios G Goulis

Dimitrios P Bogdanos

Maria G Grammatikopoulou

Affiliations

Soon will be listed here.

Abstract

The autoimmune protocol diet (AIP) is a personalized elimination diet that aims to determine and exclude the foods that might trigger immune responses, leading to inflammation and symptomatology associated with autoimmune diseases. Focusing on gut health and the importance of the gut microbiome in immune regulation and overall well-being, the AIP starts by eliminating foods that might create negative effects on the patients and continues by developing a personalized and tailored diet plan for them. This comprehensive approach aims to mitigate symptoms and improve quality of life of individuals with autoimmune conditions. This review presents and critically appraises current knowledge on the AIP protocol, highlight any oversights, and discuss findings from relevant clinical trials.

References

Gonsalves N, Yang G, Doerfler B, Ritz S, Ditto A, Hirano I . Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors. Gastroenterology. 2012; 142(7):1451-9.e1. DOI: 10.1053/j.gastro.2012.03.001. View

Gibson P, Shepherd S . Personal view: food for thought--western lifestyle and susceptibility to Crohn's disease. The FODMAP hypothesis. Aliment Pharmacol Ther. 2005; 21(12):1399-409. DOI: 10.1111/j.1365-2036.2005.02506.x. View

Masharani U, Sherchan P, Schloetter M, Stratford S, Xiao A, Sebastian A . Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes. Eur J Clin Nutr. 2015; 69(8):944-8. DOI: 10.1038/ejcn.2015.39. View

Konijeti G, Kim N, Lewis J, Groven S, Chandrasekaran A, Grandhe S . Efficacy of the Autoimmune Protocol Diet for Inflammatory Bowel Disease. Inflamm Bowel Dis. 2017; 23(11):2054-2060. PMC: 5647120. DOI: 10.1097/MIB.0000000000001221. View

Fraczek B, Pieta A, Burda A, Mazur-Kurach P, Tyrala F . Paleolithic Diet-Effect on the Health Status and Performance of Athletes?. Nutrients. 2021; 13(3). PMC: 8004139. DOI: 10.3390/nu13031019. View

Titcomb T, Bisht B, Moore 3rd D, Chhonker Y, Murry D, Snetselaar L . Eating Pattern and Nutritional Risks among People with Multiple Sclerosis Following a Modified Paleolithic Diet. Nutrients. 2020; 12(6). PMC: 7353368. DOI: 10.3390/nu12061844. View

de la O V, Zazpe I, Martinez J, Santiago S, Carlos S, Zulet M . Scoping review of Paleolithic dietary patterns: a definition proposal. Nutr Res Rev. 2020; 34(1):78-106. DOI: 10.1017/S0954422420000153. View

Nicholson L, Raveney B, Munder M . Monocyte dependent regulation of autoimmune inflammation. Curr Mol Med. 2009; 9(1):23-9. DOI: 10.2174/156652409787314499. View

Christovich A, Luo X . Gut Microbiota, Leaky Gut, and Autoimmune Diseases. Front Immunol. 2022; 13:946248. PMC: 9271567. DOI: 10.3389/fimmu.2022.946248. View

10.

Zhao Q . Bispecific Antibodies for Autoimmune and Inflammatory Diseases: Clinical Progress to Date. BioDrugs. 2020; 34(2):111-119. DOI: 10.1007/s40259-019-00400-2. View

11.

Jew S, AbuMweis S, Jones P . Evolution of the human diet: linking our ancestral diet to modern functional foods as a means of chronic disease prevention. J Med Food. 2009; 12(5):925-34. DOI: 10.1089/jmf.2008.0268. View

12.

Boers I, Muskiet F, Berkelaar E, Schut E, Penders R, Hoenderdos K . Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-study. Lipids Health Dis. 2014; 13:160. PMC: 4210559. DOI: 10.1186/1476-511X-13-160. View

13.

Akdis C . Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?. Nat Rev Immunol. 2021; 21(11):739-751. DOI: 10.1038/s41577-021-00538-7. View

14.

Szekanecz Z, McInnes I, Schett G, Szamosi S, Benko S, Szucs G . Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases. Nat Rev Rheumatol. 2021; 17(10):585-595. DOI: 10.1038/s41584-021-00652-9. View

15.

Arroyo Hornero R, Hamad I, Corte-Real B, Kleinewietfeld M . The Impact of Dietary Components on Regulatory T Cells and Disease. Front Immunol. 2020; 11:253. PMC: 7047770. DOI: 10.3389/fimmu.2020.00253. View

16.

Cashman K . Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing. Calcif Tissue Int. 2019; 106(1):14-29. DOI: 10.1007/s00223-019-00559-4. View

17.

Pelsser L, Frankena K, Toorman J, Savelkoul H, Dubois A, Pereira R . Effects of a restricted elimination diet on the behaviour of children with attention-deficit hyperactivity disorder (INCA study): a randomised controlled trial. Lancet. 2011; 377(9764):494-503. DOI: 10.1016/S0140-6736(10)62227-1. View

18.

Lindeberg S, Jonsson T, Granfeldt Y, Borgstrand E, Soffman J, Sjostrom K . A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease. Diabetologia. 2007; 50(9):1795-1807. DOI: 10.1007/s00125-007-0716-y. View

19.

Miller F . The increasing prevalence of autoimmunity and autoimmune diseases: an urgent call to action for improved understanding, diagnosis, treatment, and prevention. Curr Opin Immunol. 2022; 80:102266. PMC: 9918670. DOI: 10.1016/j.coi.2022.102266. View

20.

Shah S, Mahamat-Saleh Y, Hajji-Louati M, Correia E, Oulhote Y, Boutron-Ruault M . Palaeolithic diet score and risk of breast cancer among postmenopausal women overall and by hormone receptor and histologic subtypes. Eur J Clin Nutr. 2023; 77(5):596-602. DOI: 10.1038/s41430-023-01267-x. View