High-risk Clones Harboring β-lactamases: 2024 Update

Overview

Journal Heliyon

Date 2025 Jan 24

PMID 39850428

Authors

Veronica Roxana Flores-Vega

Santiago Partida-Sanchez

Miguel A Ares

Vianney Ortiz-Navarrete

Roberto Rosales-Reyes

Affiliations

Soon will be listed here.

Abstract

Carbapenem-resistant is defined by the World Health Organization as a "high priority" in developing new antimicrobials. Indeed, the emergence and spread of multidrug-resistant (MDR) or extensively drug-resistant (XDR) bacteria increase the morbidity and mortality risk of infected patients. Genomic variants of that display phenotypes of MDR/XDR have been defined as high-risk global clones. In this mini-review, we describe some international high-risk clones that carry β-lactamase genes that can produce chronic colonization and increase infected patients' morbidity and mortality rates.

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