Physalis Peruviana Calyces Extract Ameliorate Oxidative Stress, Inflammation, and Immune Loss in Rats-exposed to Hexaflumuron

Overview

Journal BMC Complement Med Ther

Publisher Biomed Central

Date 2025 Jan 23

PMID 39844243

Authors

Mona M Hashem

Eman I Hassanen

Neven H Hassan

Marwa A Ibrahim

Marwa Y Issa

Mohamed A Farag

Sherif A Hamdy

Affiliations

Soon will be listed here.

Abstract

Background: Hexaflumuron (HFM), a common pesticide, can disrupt the immune system and cause oxidative stress. This study investigated the potential of Physalis peruviana L. calyces extract (PP) to counteract these effects in rats.

Methods: Rats were divided into 6 groups including control, PP-treated, HFM-exposed, and co-treated (HFM + PP) groups. Immune function, antioxidant activity, and organ damage were assessed. Furthermore, UPLC-MS/MS analysis identified potential bioactive compounds in PP extract.

Results: HFM exposure suppressed immune responses and caused organ damage. Notably, the co-administration of PP extract with HFM reversed these effects, indicating its ability to reduce oxidative stress and protect the immune system. UPLC-MS/MS analysis of PP calyces ethanolic extract revealed its richness in various health-promoting metabolites, including acyl sucrose sugar, withanolides, and flavonoids, which may provide valuable insight into the underlying mechanisms of PP's calyces protective effects against HFM toxicity.

Conclusions: This study provides novel insights into the potential of P. peruviana L. calyces ethanolic extract as a natural agent to counteract the harmful effects of HFM exposure. These findings have significant implications for developing effective strategies to mitigate pesticide-induced toxicity and promote human health.

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