The Tol Pal System Integrates Maintenance of the Three Layered Cell Envelope

Overview

Journal NPJ Antimicrob Resist

Publisher Nature Portfolio

Date 2025 Jan 22

PMID 39843782

Authors

Joanna Szczepaniak

Melissa N Webby

Affiliations

Soon will be listed here.

Abstract

The rapid emergence of antibiotic-resistant superbugs poses a significant global health threat. Gram-negative bacteria are the primary culprits due to their robust, tripartite cell envelope. This review explores the emerging role of the trans-envelope Tol-Pal system in maintaining envelope integrity, by connecting envelope layers and serving as a protein interaction hub. Targeting the Tol-Pal system offers a promising approach for the development of novel envelope-disrupting antimicrobials.

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