Impact of Sjögren's Disease on Quality of Sexual Life Using the Qualisex Score

Overview

Journal RMD Open

Publisher BMJ Publishing Group

Date 2025 Jan 22

PMID 39842871

Authors

Alexandra Kachaner

Raphaele Seror

Veronique Le Guern

Philippe Dieude

Jacques-Eric Gottenberg

Eric Hachulla

Valerie Devauchelle-Pensec

Aleth Perdriger

Emanuelle Dernis

Marion Couderc

Sophie Berville

Xavier Mariette

Rakiba Belkhir

Gaetane Nocturne

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to assess the impact of Sjögren disease (SjD) on the quality of sexual life and its determinants using the Qualisex questionnaire.

Methods: The Qualisex questionnaire was administered to participants within the ASSESS cohort, a French national multicentric prospective cohort of individuals with SjD. Patients' characteristics and psychometric evaluations were also collected.

Results: Among the 395 patients of the cohort, 92 (23%) completed the questionnaire, with a median age of 56 (44-59) years and a female ratio of 92% (85/92). The median Qualisex score was 3.4 (1.1-5.9).Comparing the first and last quartiles of the Qualisex score, a worst sexual satisfaction was associated with older age (median (IQR) 58 (52-65) vs 52 (41-56) years, p=0.005), higher EULAR Sjögren's disease Patient Reported Index (ESSPRI) (6.8 (5.7-7.7) vs 4.3 (2.8-5.3), p<0.0001) lower SF-36 mental and physical scores (respectively, 43 (38-46) vs 49 (47-53), p=0.0035 and 31 (29-35) vs 35 (30-37), p=0.035), higher Depression and Anxiety scores (HADS) (respectively, 9 (7-11) vs 2 (1-4), p<0.0001 and 11 (8-14) vs 7 (4-10), p=0.006). Interestingly, EULAR Sjögren's disease Disease Activity Index (ESSDAI) score did not differ significantly (4 (1-10) vs 2.5 (1.8-4), p=0.35). In a multivariable analysis, the Qualisex score remained strongly associated with a higher HADS depression score and, to a lesser extent, with a higher ESSPRI. The inability to obtain a score was associated with older age.

Conclusion: In SjD patients, sexual satisfaction assessed with the Qualisex score, was strongly associated with depression and, to lesser extent, with ESSPRI, but not with systemic activity.

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