Risk of Infective Endocarditis Following Invasive Dental Procedures: A Systematic Review and Meta-Analysis

Overview

Journal Public Health Rev

Date 2025 Jan 22

PMID 39840023

Authors

Zhumakyz Kussainova

Mukhit Kulmaganbetov

Askar Abiltayev

Tolkyn Bulegenov

Islam Salikhanov

Affiliations

Soon will be listed here.

Abstract

Objectives: This systematic review and meta-analysis aimed to synthesize evidence and determine the association between IE and dental procedures, including invasive and non-invasive procedures.

Methods: We conducted a systematic search of PubMed, Google Scholar, and Cochrane databases for studies involving procedures such as tooth extraction, scaling, endodontic treatment, oral surgery, and periodontal treatment involving individuals aged ≥15 years. The primary outcome was the incidence of IE following these procedures.

Results: An association was found between IE and invasive dental procedures (OR 1.49, 95% CI 1.25-1.76; p < 0.00001). Subgroup analysis showed an increased risk of IE following tooth extraction (OR 2.73, 95% CI 1.46-5.11; p = 0.002) and oral surgery (OR 6.33, 95% CI 2.43-16.49; p = 0.0002) in high-risk patients.

Conclusion: Our study found a strong association between invasive dental procedures and increased IE risk, particularly for tooth extraction and oral surgery in high-risk individuals.

Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023488546, Identifier CRD42023488546.

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