» Articles » PMID: 39839895

Traditional Chinese Medicine in the Treatment of -related Gastritis: The Mechanisms of Signalling Pathway Regulations

Overview
Date 2025 Jan 22
PMID 39839895
Authors
Affiliations
Soon will be listed here.
Abstract

-associated gastritis (HPAG) is a common condition of the gastrointestinal tract. However, extensive and long-term antibiotic use has resulted in numerous adverse effects, including increased resistance, gastrointestinal dysfunction, and increased recurrence rates. When these concerns develop, traditional Chinese medicine (TCM) may have advantages. TCM is based on the concept of completeness and aims to eliminate pathogens and strengthen the body. It has the potential to prevent this condition while also boosting the rate of eradication. This review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways, which reflects the flexibility of TCM in treating diseases and the advantages of multi-level, multi-pathway, and multi-target treatments for HPAG.

References
1.
Molina-Castro S, Tiffon C, Giraud J, Boeuf H, Sifre E, Giese A . The Hippo Kinase LATS2 Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Intestinal Metaplasia in Gastric Mucosa. Cell Mol Gastroenterol Hepatol. 2019; 9(2):257-276. PMC: 6957828. DOI: 10.1016/j.jcmgh.2019.10.007. View

2.
Stambolic V, Suzuki A, de la Pompa J, Brothers G, Mirtsos C, Sasaki T . Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. 1998; 95(1):29-39. DOI: 10.1016/s0092-8674(00)81780-8. View

3.
Pei R, Jiang Y, Lei G, Chen J, Liu M, Liu S . Rhein Derivatives, A Promising Pivot?. Mini Rev Med Chem. 2020; 21(5):554-575. DOI: 10.2174/1389557520666201109120855. View

4.
Malfertheiner P, Camargo M, El-Omar E, Liou J, Peek R, Schulz C . Helicobacter pylori infection. Nat Rev Dis Primers. 2023; 9(1):19. PMC: 11558793. DOI: 10.1038/s41572-023-00431-8. View

5.
Tu K, Liu Z, Yao B, Han S, Yang W . MicroRNA-519a promotes tumor growth by targeting PTEN/PI3K/AKT signaling in hepatocellular carcinoma. Int J Oncol. 2015; 48(3):965-74. PMC: 4750540. DOI: 10.3892/ijo.2015.3309. View