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Toxicity Determined in Vitro by Morphological Alterations and Neutral Red Absorption

Overview
Journal Toxicol Lett
Publisher Elsevier
Specialty Toxicology
Date 1985 Feb 1
PMID 3983963
Citations 292
Authors
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Abstract

A method is described which combines the use of a visual morphological cytotoxicity assay with a quantitative neutral red (NR) spectrophotometric test, for the assessment of the effect of toxic agents on 3T3 cells in culture. These sensitive and reproducible assays lend themselves to a screening procedure of potential toxicants which can help reduce the use of animals for toxicity testing.

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