A Miniaturized Wireless, Battery-free Implant for In Vivo Musculoskeletal Stimulation

Overview

Journal Conf Proc (Midwest Symp Circuits Syst)

Publisher IEEE

Date 2025 Jan 22

PMID 39839201

Authors

Abed Benbuk

Diogo Moniz-Garcia

Daniel Gulick

Alfredo Quinones-Hinojosa

Jennifer Blain Christen

Affiliations

Soon will be listed here.

Abstract

We developed a miniaturized (8 × 8 mm) wireless and battery-free implant for musculoskeletal stimulation. The implant generates an monophasic voltage of up to 11.9 V in a benchtop test with an air link, and it can produce any desired stimulation protocol by responding to the reception of a 2.4 GHz wireless protocol from an external device. The test demonstrated that the implant can trigger a synchronized limb movement when targeting the gastrocnemius muscle in a rodent, with a measured limb deflection of 15 mm from resting position. The flexible substrate and ability to adjust stimulation parameters externally allow the implant to be used for a variety of applications in muscle therapy and cardiac pacing.

References

Bhatia A, Hanna J, Stuart T, Kasper K, Clausen D, Gutruf P . Wireless Battery-free and Fully Implantable Organ Interfaces. Chem Rev. 2024; 124(5):2205-2280. DOI: 10.1021/acs.chemrev.3c00425. View

Mutalib S, Mace M, Burdet E . Bimanual coordination during a physically coupled task in unilateral spastic cerebral palsy children. J Neuroeng Rehabil. 2019; 16(1):1. PMC: 6318978. DOI: 10.1186/s12984-018-0454-z. View

Alam M, Li S, Ahmed R, Yam Y, Thakur S, Wang X . Development of a battery-free ultrasonically powered functional electrical stimulator for movement restoration after paralyzing spinal cord injury. J Neuroeng Rehabil. 2019; 16(1):36. PMC: 6408863. DOI: 10.1186/s12984-019-0501-4. View

Thomaz S, Cipriano Jr G, Formiga M, Fachin-Martins E, Cipriano G, Martins W . Effect of electrical stimulation on muscle atrophy and spasticity in patients with spinal cord injury - a systematic review with meta-analysis. Spinal Cord. 2019; 57(4):258-266. DOI: 10.1038/s41393-019-0250-z. View

Synnot A, Chau M, Pitt V, OConnor D, Gruen R, Wasiak J . Interventions for managing skeletal muscle spasticity following traumatic brain injury. Cochrane Database Syst Rev. 2017; 11:CD008929. PMC: 6486165. DOI: 10.1002/14651858.CD008929.pub2. View

Gutruf P, Yin R, Lee K, Ausra J, Brennan J, Qiao Y . Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models. Nat Commun. 2019; 10(1):5742. PMC: 6917818. DOI: 10.1038/s41467-019-13637-w. View

Jitkritsadakul O, Bhidayasiri R, Kalia S, Hodaie M, Lozano A, Fasano A . Systematic review of hardware-related complications of Deep Brain Stimulation: Do new indications pose an increased risk?. Brain Stimul. 2017; 10(5):967-976. DOI: 10.1016/j.brs.2017.07.003. View

Cai L, Burton A, Gonzales D, Kasper K, Azami A, Peralta R . Osseosurface electronics-thin, wireless, battery-free and multimodal musculoskeletal biointerfaces. Nat Commun. 2021; 12(1):6707. PMC: 8602388. DOI: 10.1038/s41467-021-27003-2. View

Moritani T . Electrical muscle stimulation: Application and potential role in aging society. J Electromyogr Kinesiol. 2021; 61:102598. DOI: 10.1016/j.jelekin.2021.102598. View

Ausra J, Madrid M, Yin R, Hanna J, Arnott S, Brennan J . Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation. Sci Adv. 2022; 8(43):eabq7469. PMC: 9604544. DOI: 10.1126/sciadv.abq7469. View