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Location of Gene for Beta Subunit of Human T-cell Receptor at Band 7q35, a Region Prone to Rearrangements in T Cells

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Journal Science
Specialty Science
Date 1985 May 3
PMID 3983641
Citations 31
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Abstract

The T-cell receptor is formed by two chains, alpha and beta, for which specific clones were recently obtained. In this report the gene for the beta chain of the human T-cell receptor was located on the long arm of chromosome 7, band q35, by means of in situ hybridization. This chromosome region in T cells is unusually prone to develop breaks in vivo, perhaps reflecting instability generated by somatic rearrangement of T-cell receptor genes during normal differentiation in this cell lineage.

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