The Role of Cell Cycle-related Genes in the Tumorigenesis of Adrenal and Thyroid Neuroendocrine Tumors

Overview

Journal Heliyon

Date 2025 Jan 21

PMID 39834406

Authors

Ekaterina Filipovich

Ekaterina Gorodkova

Anastasia Shcherbakova

Walaa Asaad

Sergey Popov

Galina Melnichenko

Natalya Mokrysheva

Marina Utkina

Affiliations

Soon will be listed here.

Abstract

The molecular mechanisms underlying adrenal and thyroid neuroendocrine tumors, including their tumorigenesis, progression, and metastasis, involve unique pathways regulating cell cycle progression. To better understand these mechanisms and pathways, extensive in-depth research on cell cycle-related genes is necessary. This review aims to describe and interpret current single-cell RNA sequencing studies on neuroblastoma, medullary thyroid cancer, and pheochromocytoma tumors. Our review summarizes differentially expressed cell cycle-related genes with distinct functions, highlighting their potential as therapeutic targets and components of panels used to determine tumor type or aggressiveness. Although some insights have been gained, there is still limited information on these topics, and further research is required to explore the regulatory mechanisms of these tumors.

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