What We Know About TMEM175 in Parkinson's Disease

Overview

Journal CNS Neurosci Ther

Date 2025 Jan 21

PMID 39834146

Authors

Jing Wang

Xuechun Sun

Lufeng Cheng

Meijie Qu

Chanyuan Zhang

Xueting Li

Lingyan Zhou

Affiliations

Soon will be listed here.

Abstract

Background: Lysosome is a highly heterogeneous membranous organelle in eukaryotic cells, which regulates many physiological processes in the cell. Studies have found that lysosomal dysfunction disrupts cellular homeostasis and is associated with Parkinson's disease (PD). Transmembrane protein 175 (TMEM175) is a lysosomal cation channel whose activity is essential for lysosomal homeostasis. At present, it has been confirmed that TMEM175 is related to the pathogenesis of PD, but the relationship between the two remains unclear.

Aims: A thorough comprehension of the structure and function of TMEM175 would greatly contribute to elucidating the achievement of this objective. In this paper, the structure, composition, and function of TMEM175 and its relationship with PD will be reviewed.

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