A High-valence Bismuth(V) Nanoplatform Triggers Cancer Cell Death and Anti-tumor Immune Responses with Exogenous Excitation-free Endogenous HO- and O-independent ROS Generation

Overview

Journal Nat Commun

Date 2025 Jan 20

PMID 39833161

Authors

Yizhang Tang

Xujiang Yu

Liangrui He

Meng Tang

Wenji Yue

Ruitong Chen

Jie Zhao

Qi Pan

Wanwan Li

Affiliations

Soon will be listed here.

Abstract

Reactive oxygen species with evoked immunotherapy holds tremendous promise for cancer treatment but has limitations due to its dependence on exogenous excitation and/or endogenous HO and O. Here we report a versatile oxidizing pentavalent bismuth(V) nanoplatform (NaBiO-PEG) can generate reactive oxygen species in an excitation-free and HO- and O-independent manner. Upon exposure to the tumor microenvironment, NaBiO-PEG undergoes continuous H-accelerated hydrolysis with •OH and O generation through electron transfer-mediated Bi-to-Bi conversion and lattice oxygen transformation. The simultaneous release of sodium counterions after endocytosis triggers caspase-1-mediated pyroptosis. NaBiO-PEG intratumorally administered initiates robust therapeutic efficacies against both primary and distant tumors and activates systemic immune responses to combat tumor metastasis. NaBiO-PEG intravenously administered can efficiently accumulate at the tumor site for further real-time computed tomography monitoring, immunotherapy, or alternative synergistic immune-radiotherapy. Overall, this work offers a nanomedicine based on high-valence bismuth(V) nanoplatform and underscores its great potential for cancer immunotherapy.

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