Potential Antihyperlipidemic Effects of Myrcenol and Curzerene in High-fat Fed Rats

Overview

Journal BMC Pharmacol Toxicol

Publisher Biomed Central

Date 2025 Jan 17

PMID 39825436

Authors

Sana Tahir

Abdullah Abdo

Aisha Mobashar

Arham Shabbir

Komal Najam

Aisha Ibrahim

Khalid Hussain

Yousef A Bin Jardan

Samir Ibenmoussa

Youssouf Ali Younous

Affiliations

Soon will be listed here.

Abstract

The study evaluated the anti-hyperlipidemic effects of myrcenol and curzerene on a high fat diet induced hyperlipidemia rat model. Thirty male albino rats were fed on a high-fat diet for four months. The HFD-induced hyperperlipidemia rats were treated with rosuvastatin (10 mg/kg), curzerene (130 mg/kg) and myrcenol (100 mg/kg) for four weeks. Blood samples were collected for further analysis. Aorta and heart were harvested for histopathological evaluation. Hepatic lipase and HMG-CoA reductase were determined by ELISA. FST and Y-maze tests were performed to assess the stress level in hyperlipidemia rats. The phytochemical compounds (Curzerene and Myrcenol) and the standard drug (Rosuvastatin) resulted in decreased body weight as well as reduced levels of LDL, TG, TC, AST and ALT as compared to the diseased group. Additionally, the treated groups displayed improved HDL levels and less depressed behavior. The ELISA results revealed that the Curzerene and myrcenol had significantly increased the protein concentration of hepatic lipase than the diseased group whereas both compounds significantly lowered the HMG-CoA reductase concentrations compared to the diseased group. The findings suggested that myrcenol and curzerene had the potential to be therapeutic agents for managing hyperlipidemia and reducing the risk of heart-related conditions associated with high lipid levels.

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