Nuclear Factor of Activated T Cells (NFAT) Proteins As Targeted Molecules in Diseases: A Narrative Review

Overview

Journal Cureus

Date 2025 Jan 17

PMID 39822413

Authors

Mohadese Mozafari

Siti Nurnasihah Md Hashim

Khairul Bariah Ahmad Amin Noordin

Siti Aishah Zainal

Ahmad Azlina

Affiliations

Soon will be listed here.

Abstract

The nuclear factor of activated T cells (NFAT) is a key player in the NFAT pathway, regulating various cellular processes physiologically and pathologically. NFAT signaling is implicated in developing multiple diseases, such as cancer progression, that are associated with angiogenesis. Despite numerous studies on NFAT, there is still a dearth of information on the proteins and signaling pathway compared to other established pathways. With five NFAT proteins in the spotlight, this review aims to update the understanding of their roles and signaling by analyzing the most recent studies on the NFAT pathway. The recent insights into NFAT proteins and their association with diseases enhance our understanding of these proteins and open the possibility of developing therapeutic strategies for such diseases.

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