Potential Effects of Liver Dysfunction at the Time of Diagnosis in Patients with Acute Myeloid Leukemia

Whilst severe liver dysfunction is rarely encountered at the time of diagnosis for patients with acute myeloid leukemia (AML), mild elevations aminotransferase (<5 times the upper limit of normal) may be more frequently seen. Liver dysfunction at the time of diagnosis of AML is a parameter that requires investigation and can assist the clinicians in predicting prognosis. The aim of the present study was to investigate liver dysfunction at the time of diagnosis using the assoicated parameters in patients with AML. The present retrospective study included 90 patients diagnosed with AML who were hospitalised in the Hematology Clinic of Dışkapı Yıldırım Beyazıt Training and Research Hospital (Ankara, Turkey). The demographic characteristics of the patients were recorded together with hemogram results, anemia parameters, measurable residual disease positivity (MRD) and risk category, the presence of hepatosplenomegaly, infection, neutrophil recovery time (NRT), platelet recovery time (PRT) and liver dysfunction. The patients were analyzed in two groups following sorting into the liver dysfunction (n=45) and normal liver function test group (n=45). In the analysis of independent quantitative data (age, white blood cell count, hemoglobin, platelet, international normalized ratio, albumin, B12 vitamin, NRT, PRT) the Mann Whitney U-test was used. Independent qualitative data (sex, hepatomegaly, splenomegaly, MRD, risk category, infection) were analyzed using the χ test or the Fischer test. The effect level was investigated using univariate and multivariate logistic regression. A receiver operating characteristic curve was applied to determine the effect level and cut-off values. In the group with liver dysfunction, NRT, PRT, MRD positivity, risk category and the presence of infection were found to be statistically significantly higher. These findings suggest that during the first evaluation of patients diagnosed with AML, liver function tests are simple, rapid and necessary. The results obtained in the present study showed that liver dysfunction at diagnosis can be associated with the high-risk group, in addition to more frequent infection, poorer prognosis and mortality.