Vitamin D Controversies in the Laboratory Medicine: A Review of Clinical Guidelines and Recommendations

Overview

Journal EJIFCC

Date 2025 Jan 15

PMID 39810891

Authors

Maria Monsalud Arrebola

Xavier Filella

Maria Dolores Albaladejo-Oton

Nuria Gimenez

Maria Gemma Serrano-Olmedo

Rafael Jose Garcia-Martinez

Elena Bonet-Estruch

Maria Santamaria-Gonzalez

Diana Perez-Torrella

Daniel Morell-Garcia

Juan Antonio Allue-Palacin

Maria Angels Ruiz-Minguez

Miguel Angel Castano-Lopez

Affiliations

Soon will be listed here.

Abstract

A narrative review of the main guidelines and recommendations published from 2011 up to date about the status of vitamin D deficiency has been carried out. The objective of this review is to discuss the origin of the controversy about the status of this entity, as well as the evolution of the methodological aspects and clinical situations that require vitamin D screening. The results obtained indicate that the criteria defining vitamin D status, according to two studies published in 2011, the Institute of Medicine (IOM) recommendations and the Endocrine Society (ES) guidelines, regardless the affected population. Concerning the methodology used, progress has been made thanks to the Vitamin D Standardization Program (VDSP), although the most recent results from the external Vitamin D External Quality Program Assessment Scheme (DEQAS) indicate that there is still a significant bias among the different immunoassays available. In relation to the criteria for screening, an agreement is observed in the most recent publications.

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