When the Mask Slips: A Peripheral T-cell Lymphoma Disguised As Lupus with Myelofibrosis in a Patient with May-Hegglin Syndrome

Overview

Journal Leuk Res Rep

Date 2025 Jan 14

PMID 39807111

Authors

V Da Silva Constante

H Couvert

A Wolfromm

M Ilzkovitz

Affiliations

Soon will be listed here.

Abstract

We describe the case of a female patient with May-Hegglin syndrome who developed peripheral T-cell lymphoma not otherwise specified. The patient presents with systemic lupus erythematous phenotype and myelofibrosis secondary to T-cell lymphoma. Peripheral T-cell lymphoma not otherwise specified, represents 25 % of all peripheral T-cell lymphoma. Its diagnosis remains challenging due to the polymorphous clinical presentation and pathological heterogeneity. Myelofibrosis associated with malignant lymphomas is rare and peripheral T-cell lymphoma is even rarer. To our knowledge, this is the first case to describe an association between May-Hegglin syndrome and a peripheral T-cell lymphoma.

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