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Resolution of Hypogammaglobulinemia-associated Recurrent Bacteraemia After Hematopoietic Cell Transplantation (HCT)

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Date 2025 Jan 13
PMID 39802398
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Abstract

Primary or secondary hypogammaglobulinemia is associated with persistent norovirus and infections despite immunoglobulin replacement therapy. Allogeneic hematopoietic cell transplantation for hematologic indications can lead to immune reconstitution by correcting a previously undiagnosed concurrent primary immunodeficiency.

References
1.
Otani I, Lehman H, Jongco A, Tsao L, Azar A, Tarrant T . Practical guidance for the diagnosis and management of secondary hypogammaglobulinemia: A Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees. J Allergy Clin Immunol. 2022; 149(5):1525-1560. DOI: 10.1016/j.jaci.2022.01.025. View

2.
Grammatikos A, Thomas M, Johnston S, Moghaddas F, Albur M, Yong P . Chronic or recurrent Campylobacter enteritis in primary immunodeficiency: A UK national case-series and review of the literature. J Allergy Clin Immunol Pract. 2023; 11(9):2948-2954.e4. DOI: 10.1016/j.jaip.2023.05.046. View

3.
Ballow M, Sanchez-Ramon S, Walter J . Secondary Immune Deficiency and Primary Immune Deficiency Crossovers: Hematological Malignancies and Autoimmune Diseases. Front Immunol. 2022; 13:928062. PMC: 9340211. DOI: 10.3389/fimmu.2022.928062. View

4.
Dion J, Malphettes M, Benejat L, Megraud F, Wargnier A, Boutboul D . Campylobacter infection in adult patients with primary antibody deficiency. J Allergy Clin Immunol Pract. 2018; 7(3):1038-1041.e4. DOI: 10.1016/j.jaip.2018.06.014. View

5.
Athni T, Barmettler S . Hypogammaglobulinemia, late-onset neutropenia, and infections following rituximab. Ann Allergy Asthma Immunol. 2023; 130(6):699-712. PMC: 10247428. DOI: 10.1016/j.anai.2023.01.018. View